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Chromosomally unstable tumor cells specifically require KIF18A for proliferation

Chromosomal instability (CIN) is a hallmark of tumor cells caused by changes in the dynamics and control of microtubules that compromise the mitotic spindle. Thus, CIN cells may respond differently than diploid cells to treatments that target mitotic spindle regulation. Here, we test this idea by in...

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Detalles Bibliográficos
Autores principales:	Marquis, Carolyn, Fonseca, Cindy L., Queen, Katelyn A., Wood, Lisa, Vandal, Sarah E., Malaby, Heidi L. H., Clayton, Joseph E., Stumpff, Jason
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900194/ https://www.ncbi.nlm.nih.gov/pubmed/33619254 http://dx.doi.org/10.1038/s41467-021-21447-2

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