TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells

This study focused on characterizing the potential mechanism of valvular toxicity caused by TGFβ receptor inhibitors (TGFβRis) using rat valvular interstitial cells (VICs) to evaluate early biological responses to TGFβR inhibition. Three TGFβRis that achieved similar exposures in the rat were assess...

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Detalles Bibliográficos
Autores principales: Wang, Faye, Zhang, Cindy, Kwagh, Jae, Strassle, Brian, Li, Jinqing, Huang, Minxue, Song, Yunling, Lehman, Brenda, Westhouse, Richard, Palanisamy, Kamalavenkatesh, Holenarsipur, Vinay K., Borzilleri, Robert, Augustine-Rauch, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900227/
https://www.ncbi.nlm.nih.gov/pubmed/33665554
http://dx.doi.org/10.1016/j.isci.2021.102133

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