Inhibition of Small-Conductance Calcium-Activated Potassium Current (I(K,Ca)) Leads to Differential Atrial Electrophysiological Effects in a Horse Model of Persistent Atrial Fibrillation

BACKGROUND: Small-conductance Ca(2+)-activated K(+) (K(Ca)2) channels have been proposed as a possible atrial-selective target to pharmacologically terminate atrial fibrillation (AF) and to maintain sinus rhythm. However, it has been hypothesized that the importance of the K(Ca)2 current—and thereby...

Descripción completa

Detalles Bibliográficos
Autores principales: Fenner, Merle Friederike, Gatta, Giulia, Sattler, Stefan, Kuiper, Marion, Hesselkilde, Eva Melis, Adler, Ditte M. T., Smerup, Morten, Schotten, Ulrich, Sørensen, Ulrik, Diness, Jonas Goldin, Jespersen, Thomas, Verheule, Sander, Van Hunnik, Arne, Buhl, Rikke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900437/
https://www.ncbi.nlm.nih.gov/pubmed/33633584
http://dx.doi.org/10.3389/fphys.2021.614483

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900437/
https://www.ncbi.nlm.nih.gov/pubmed/33633584
http://dx.doi.org/10.3389/fphys.2021.614483

Ejemplares similares