PIP(2) promotes conformation-specific dimerization of the EphA2 membrane region

The impact of the EphA2 receptor on cancer malignancy hinges on the two different ways it can be activated. EphA2 induces antioncogenic signaling after ligand binding, but ligand-independent activation of EphA2 is pro-oncogenic. It is believed that the transmembrane (TM) domain of EphA2 adopts two a...

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Detalles Bibliográficos
Autores principales: Stefanski, Katherine M., Russell, Charles M., Westerfield, Justin M., Lamichhane, Rajan, Barrera, Francisco N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900517/
https://www.ncbi.nlm.nih.gov/pubmed/33277361
http://dx.doi.org/10.1074/jbc.RA120.016423

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900517/
https://www.ncbi.nlm.nih.gov/pubmed/33277361
http://dx.doi.org/10.1074/jbc.RA120.016423

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