Cargando…

The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors

Identification of novel tumor-specific targets is important for the future development of immunotherapeutic strategies using genetically engineered T cells or vaccines. In this study, we characterized the expression of VCX2, a member of the VCX/Y cancer/testis antigen family, in a large panel of nor...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jakobsen, Mie K., Traynor, Sofie, Stæhr, Mette, Duijf, Pascal G., Nielsen, Aaraby Y., Terp, Mikkel G., Pedersen, Christina B., Guldberg, Per, Ditzel, Henrik J., Gjerstorff, Morten F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900521/ https://www.ncbi.nlm.nih.gov/pubmed/33634013 http://dx.doi.org/10.3389/fonc.2020.584024

Ejemplares similares

The role of GAGE cancer/testis antigen in metastasis: the jury is still out
por: Gjerstorff, Morten Frier, et al.
Publicado: (2016)

Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability
por: Nielsen, Aaraby Yoheswaran, et al.
Publicado: (2016)

PDX Models: A Versatile Tool for Studying the Role of Myeloid-Derived Suppressor Cells in Breast Cancer
por: Gjerstorff, Morten F., et al.
Publicado: (2022)

CAR T-Cell Cancer Therapy Targeting Surface Cancer/Testis Antigens
por: Jakobsen, Mie K., et al.
Publicado: (2020)

ZBED1 Regulates Genes Important for Multiple Biological Processes of the Placenta
por: Johansen, Simone, et al.
Publicado: (2022)

Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins
por: Traynor, Sofie, et al.
Publicado: (2019)

Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes
por: Terp, Mikkel G., et al.
Publicado: (2021)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence
por: Brückmann, Nadine H., et al.
Publicado: (2019)

Oncogenic cancer/testis antigens: prime candidates for immunotherapy
por: Gjerstorff, Morten F., et al.
Publicado: (2015)

Analysis of GAGE, NY-ESO-1 and SP17 cancer/testis antigen expression in early stage non-small cell lung carcinoma
por: Gjerstorff, Morten F, et al.
Publicado: (2013)

SSX addiction in melanoma propagates tumor growth and metastasis
por: Traynor, Sofie, et al.
Publicado: (2022)

Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers
por: Hansen, Simone Valentin, et al.
Publicado: (2018)

Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity
por: Gammelgaard, Odd L, et al.
Publicado: (2022)

Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer
por: Maheswaran, Emeaga, et al.
Publicado: (2015)

HMGA2 Supports Cancer Hallmarks in Triple-Negative Breast Cancer
por: Mansoori, Behzad, et al.
Publicado: (2021)

Natural Products Impacting DNA Methyltransferases and Histone Deacetylases
por: Akone, Sergi Herve, et al.
Publicado: (2020)

HMGA2 as a Critical Regulator in Cancer Development
por: Mansoori, Behzad, et al.
Publicado: (2021)

Inhibition of Histone Methyltransferase, Histone Deacetylase, and β-Catenin Synergistically Enhance the Cardiac Potential of Bone Marrow Cells
por: Yang, Jinpu, et al.
Publicado: (2017)

Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma
por: Phimmachanh, Monica, et al.
Publicado: (2020)

Contrasting roles for DNA methyltransferases and histone deacetylases in single-item and associative recognition memory
por: Scott, Hannah, et al.
Publicado: (2017)

Copy number gain of VCX, X-linked multi-copy gene, leads to cell proliferation and apoptosis during spermatogenesis
por: Ji, Juan, et al.
Publicado: (2016)

The clinical advantage of fixed 8-mm diameter VCX stents over underdilated VTS stents is not established in refractory ascites
por: Mansour, Sohaïb, et al.
Publicado: (2021)

Epigenetic Regulation of Host Defense Peptide Synthesis: Synergy Between Histone Deacetylase Inhibitors and DNA/Histone Methyltransferase Inhibitors
por: Whitmore, Melanie A., et al.
Publicado: (2022)

Human cancer evolution in the context of a human immune system in mice
por: Gammelgaard, Odd L., et al.
Publicado: (2018)

Reply to: “The clinical advantage of fixed 8-mm diameter VCX stents over underdilated VTS stents is not established in refractory ascites”
por: Praktiknjo, Michael, et al.
Publicado: (2021)

Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
por: Tran, Huong Thi Thanh, et al.
Publicado: (2013)

Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
por: Yao, Ya-Li, et al.
Publicado: (2011)

Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues
por: GU, YIFENG, et al.
Publicado: (2013)

Combination of IL-2, rapamycin, DNA methyltransferase and histone deacetylase inhibitors for the expansion of human regulatory T cells
por: Miyara, Makoto, et al.
Publicado: (2016)

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers
por: Sanaei, Masumeh, et al.
Publicado: (2019)

Targeting histone deacetylases for the treatment of disease
por: Lawless, M W, et al.
Publicado: (2009)

The histone methyltransferase SET8 is required for S-phase progression
por: Jørgensen, Stine, et al.
Publicado: (2007)

Targeting Huntington’s disease through histone deacetylases
por: Gray, Steven G.
Publicado: (2011)

Chemical Phylogenetics of Histone Deacetylases
por: Bradner, James E., et al.
Publicado: (2010)

Histone deacetylases in viral infections
por: Herbein, Georges, et al.
Publicado: (2010)

Butyrate Histone Deacetylase Inhibitors
por: Steliou, Kosta, et al.
Publicado: (2012)

Histone deacetylase signaling in cardioprotection
por: Lehmann, Lorenz H., et al.
Publicado: (2013)

Histone deacetylase 6 in cancer
por: Li, Ting, et al.
Publicado: (2018)

Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia
por: Pfeiffer, Matthias Manuel, et al.
Publicado: (2013)

Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors
por: Su, Yanrong, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_1q3tb88m4ignvr709go1bnm2fr