Cargando…

Silencing of the tRNA Modification Enzyme Cdkal1 Effects Functional Insulin Synthesis in NIT-1 Cells: tRNA(Lys3) Lacking ms(2)- (ms(2)t(6)A(37)) is Unable to Establish Sufficient Anticodon:Codon Interactions to Decode the Wobble Codon AAG

Human Genome Wide Association Studies found a significant risk of Type 2 Diabetes Mellitus (T2DM) in single nucleotide polymorphisms in the cdkal1 gene. The cdkal1 gene is remote from the insulin gene and with the surprising function of a specific tRNA modification. Population studies and case contr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Narendran, Amithi, Vangaveti, Sweta, Ranganathan, Srivathsan V., Eruysal, Emily, Craft, Miranda, Alrifai, Omar, Chua, Fu Yee, Sarachan, Kathryn, Litwa, Breann, Ramachandran, Sheetal, Agris, Paul F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900539/ https://www.ncbi.nlm.nih.gov/pubmed/33634165 http://dx.doi.org/10.3389/fmolb.2020.584228

Ejemplares similares

Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function
por: Väre, Ville Y. P., et al.
Publicado: (2017)

Decoding system for the AUA codon by tRNA(Ile) with the UAU anticodon in Mycoplasma mobile
por: Taniguchi, Takaaki, et al.
Publicado: (2013)

Effects of tRNA modification on translational accuracy depend on intrinsic codon–anticodon strength
por: Manickam, Nandini, et al.
Publicado: (2016)

ACEing premature codon termination using anticodon-engineered sup-tRNA-based therapy
por: Lin, Ting-Yu, et al.
Publicado: (2022)

Codon-specific effects of tRNA anticodon loop modifications on translational misreading errors in the yeast Saccharomyces cerevisiae
por: Joshi, Kartikeya, et al.
Publicado: (2018)

Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing
por: Hoffer, Eric D, et al.
Publicado: (2020)

Celebrating wobble decoding: Half a century and still much is new
por: Agris, Paul F., et al.
Publicado: (2017)

Modelling the Efficiency of Codon–tRNA Interactions Based on Codon Usage Bias
por: Sabi, Renana, et al.
Publicado: (2014)

Translation of non-standard codon nucleotides reveals minimal requirements for codon-anticodon interactions
por: Hoernes, Thomas Philipp, et al.
Publicado: (2018)

tRNA anticodon shifts in eukaryotic genomes
por: Rogers, Hubert H., et al.
Publicado: (2014)

A Major Controversy in Codon-Anticodon Adaptation Resolved by a New Codon Usage Index
por: Xia, Xuhua
Publicado: (2015)

Unconventional decoding of the AUA codon as methionine by mitochondrial tRNA(Met) with the anticodon f(5)CAU as revealed with a mitochondrial in vitro translation system
por: Takemoto, Chie, et al.
Publicado: (2009)

Protein Synthesis in E. coli: Dependence of Codon-Specific Elongation on tRNA Concentration and Codon Usage
por: Rudorf, Sophia, et al.
Publicado: (2015)

Construction of anti-codon table of the plant kingdom and evolution of tRNA selenocysteine (tRNA(Sec))
por: Mohanta, Tapan Kumar, et al.
Publicado: (2020)

The 'polysemous' codon--a codon with multiple amino acid assignment caused by dual specificity of tRNA identity.
por: Suzuki, T, et al.
Publicado: (1997)

The effect of tRNA levels on decoding times of mRNA codons
por: Dana, Alexandra, et al.
Publicado: (2014)

tRNA-mediated codon-biased translation in mycobacterial hypoxic persistence
por: Chionh, Yok Hian, et al.
Publicado: (2016)

Efficiency of protein synthesis inhibition depends on tRNA and codon compositions
por: Rudorf, Sophia
Publicado: (2019)

A rationale for tRNA modification circuits in the anticodon loop
por: Han, Lu, et al.
Publicado: (2018)

Synthesis and investigation of the 5-formylcytidine modified, anticodon stem and loop of the human mitochondrial tRNA(Met)
por: Lusic, Hrvoje, et al.
Publicado: (2008)

An unusual tRNA(Thr) derived from tRNA(His) reassigns in yeast mitochondria the CUN codons to threonine
por: Su, Dan, et al.
Publicado: (2011)

An improved estimation of tRNA expression to better elucidate the coevolution between tRNA abundance and codon usage in bacteria
por: Wei, Yulong, et al.
Publicado: (2019)

A tRNA-mimic Strategy to Explore the Role of G34 of tRNA(Gly) in Translation and Codon Frameshifting
por: Janvier, Aurélie, et al.
Publicado: (2019)

Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase
por: Liu, Sheng, et al.
Publicado: (2016)

Real-time tRNA transit on single translating ribosomes at codon resolution
por: Uemura, Sotaro, et al.
Publicado: (2010)

Codon-Specific Translation by m(1)G37 Methylation of tRNA
por: Hou, Ya-Ming, et al.
Publicado: (2019)

tRNA epitranscriptomics and biased codon are linked to proteome expression in Plasmodium falciparum
por: Ng, Chee Sheng, et al.
Publicado: (2018)

Multiplex suppression of four quadruplet codons via tRNA directed evolution
por: DeBenedictis, Erika A., et al.
Publicado: (2021)

tRNA methylation resolves codon usage bias at the limit of cell viability
por: Masuda, Isao, et al.
Publicado: (2022)

Split aminoacyl-tRNA synthetases for proximity-induced stop codon suppression
por: Jiang, Han-Kai, et al.
Publicado: (2023)

Differential annotation of tRNA genes with anticodon CAT in bacterial genomes
por: Silva, Francisco J., et al.
Publicado: (2006)

Exploring GpG bases next to anticodon in tRNA subsets
por: Srinivasan, Thangavelu, et al.
Publicado: (2013)

Anticodon sequence determines the impact of mistranslating tRNA(Ala) variants
por: Cozma, Ecaterina, et al.
Publicado: (2023)

Factors That Shape Eukaryotic tRNAomes: Processing, Modification and Anticodon–Codon Use
por: Maraia, Richard J., et al.
Publicado: (2017)

Suppression of Amber Codons in Caulobacter crescentus by the Orthogonal Escherichia coli Histidyl-tRNA Synthetase/tRNA(His) Pair
por: Ko, Jae-hyeong, et al.
Publicado: (2013)

A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code
por: Kim, Yunsoo, et al.
Publicado: (2019)

Mutations in the anticodon stem of tRNA cause accumulation and Met22-dependent decay of pre-tRNA in yeast
por: Payea, Matthew J., et al.
Publicado: (2020)

“Superwobbling” and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code
por: Lei, Lei, et al.
Publicado: (2022)

The structure of the human tRNA(Lys3) anticodon bound to the HIV genome is stabilized by modified nucleosides and adjacent mismatch base pairs
por: Bilbille, Yann, et al.
Publicado: (2009)

tRNA properties help shape codon pair preferences in open reading frames
por: Buchan, J. Ross, et al.
Publicado: (2006)

Cannot write session to /tmp/vufind_sessions/sess_13soao8s24mp7fmqvcte216l98