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Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia
Slow oscillations are a pattern of synchronized network activity generated by the cerebral cortex. They consist of Up and Down states, which are periods of activity interspersed with periods of silence, respectively. However, even when this is a unique dynamic regime of transitions between Up and Do...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900541/ https://www.ncbi.nlm.nih.gov/pubmed/33633546 http://dx.doi.org/10.3389/fnsys.2021.609645 |
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author | Torao-Angosto, Melody Manasanch, Arnau Mattia, Maurizio Sanchez-Vives, Maria V. |
author_facet | Torao-Angosto, Melody Manasanch, Arnau Mattia, Maurizio Sanchez-Vives, Maria V. |
author_sort | Torao-Angosto, Melody |
collection | PubMed |
description | Slow oscillations are a pattern of synchronized network activity generated by the cerebral cortex. They consist of Up and Down states, which are periods of activity interspersed with periods of silence, respectively. However, even when this is a unique dynamic regime of transitions between Up and Down states, this pattern is not constant: there is a range of oscillatory frequencies (0.1–4 Hz), and the duration of Up vs. Down states during the cycles is variable. This opens many questions. Is there a constant relationship between the duration of Up and Down states? How much do they vary across conditions and oscillatory frequencies? Are there different sub regimes within the slow oscillations? To answer these questions, we aimed to explore a concrete aspect of slow oscillations, Up and Down state durations, across three conditions: deep anesthesia, light anesthesia, and slow-wave sleep (SWS), in the same chronically implanted rats. We found that light anesthesia and SWS have rather similar properties, occupying a small area of the Up and Down state duration space. Deeper levels of anesthesia occupy a larger region of this space, revealing that a large variety of Up and Down state durations can emerge within the slow oscillatory regime. In a network model, we investigated the network parameters that can explain the different points within our bifurcation diagram in which slow oscillations are expressed. |
format | Online Article Text |
id | pubmed-7900541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79005412021-02-24 Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia Torao-Angosto, Melody Manasanch, Arnau Mattia, Maurizio Sanchez-Vives, Maria V. Front Syst Neurosci Neuroscience Slow oscillations are a pattern of synchronized network activity generated by the cerebral cortex. They consist of Up and Down states, which are periods of activity interspersed with periods of silence, respectively. However, even when this is a unique dynamic regime of transitions between Up and Down states, this pattern is not constant: there is a range of oscillatory frequencies (0.1–4 Hz), and the duration of Up vs. Down states during the cycles is variable. This opens many questions. Is there a constant relationship between the duration of Up and Down states? How much do they vary across conditions and oscillatory frequencies? Are there different sub regimes within the slow oscillations? To answer these questions, we aimed to explore a concrete aspect of slow oscillations, Up and Down state durations, across three conditions: deep anesthesia, light anesthesia, and slow-wave sleep (SWS), in the same chronically implanted rats. We found that light anesthesia and SWS have rather similar properties, occupying a small area of the Up and Down state duration space. Deeper levels of anesthesia occupy a larger region of this space, revealing that a large variety of Up and Down state durations can emerge within the slow oscillatory regime. In a network model, we investigated the network parameters that can explain the different points within our bifurcation diagram in which slow oscillations are expressed. Frontiers Media S.A. 2021-02-09 /pmc/articles/PMC7900541/ /pubmed/33633546 http://dx.doi.org/10.3389/fnsys.2021.609645 Text en Copyright © 2021 Torao-Angosto, Manasanch, Mattia and Sanchez-Vives. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Torao-Angosto, Melody Manasanch, Arnau Mattia, Maurizio Sanchez-Vives, Maria V. Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia |
title | Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia |
title_full | Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia |
title_fullStr | Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia |
title_full_unstemmed | Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia |
title_short | Up and Down States During Slow Oscillations in Slow-Wave Sleep and Different Levels of Anesthesia |
title_sort | up and down states during slow oscillations in slow-wave sleep and different levels of anesthesia |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900541/ https://www.ncbi.nlm.nih.gov/pubmed/33633546 http://dx.doi.org/10.3389/fnsys.2021.609645 |
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