The Complexity of the cGAS-STING Pathway in CNS Pathologies

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammatio...

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Autores principales: Fryer, Amelia L., Abdullah, Amar, Taylor, Juliet M., Crack, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900568/
https://www.ncbi.nlm.nih.gov/pubmed/33633536
http://dx.doi.org/10.3389/fnins.2021.621501
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author Fryer, Amelia L.
Abdullah, Amar
Taylor, Juliet M.
Crack, Peter J.
author_facet Fryer, Amelia L.
Abdullah, Amar
Taylor, Juliet M.
Crack, Peter J.
author_sort Fryer, Amelia L.
collection PubMed
description Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammation. As an upstream regulator of type-I IFNs, STING modulation presents a novel therapeutic opportunity to mediate inflammation in the CNS. This review will detail the current knowledge of protective and detrimental STING activity in acute and chronic CNS pathologies and the current therapeutic avenues being explored.
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spelling pubmed-79005682021-02-24 The Complexity of the cGAS-STING Pathway in CNS Pathologies Fryer, Amelia L. Abdullah, Amar Taylor, Juliet M. Crack, Peter J. Front Neurosci Neuroscience Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammation. As an upstream regulator of type-I IFNs, STING modulation presents a novel therapeutic opportunity to mediate inflammation in the CNS. This review will detail the current knowledge of protective and detrimental STING activity in acute and chronic CNS pathologies and the current therapeutic avenues being explored. Frontiers Media S.A. 2021-02-09 /pmc/articles/PMC7900568/ /pubmed/33633536 http://dx.doi.org/10.3389/fnins.2021.621501 Text en Copyright © 2021 Fryer, Abdullah, Taylor and Crack. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Fryer, Amelia L.
Abdullah, Amar
Taylor, Juliet M.
Crack, Peter J.
The Complexity of the cGAS-STING Pathway in CNS Pathologies
title The Complexity of the cGAS-STING Pathway in CNS Pathologies
title_full The Complexity of the cGAS-STING Pathway in CNS Pathologies
title_fullStr The Complexity of the cGAS-STING Pathway in CNS Pathologies
title_full_unstemmed The Complexity of the cGAS-STING Pathway in CNS Pathologies
title_short The Complexity of the cGAS-STING Pathway in CNS Pathologies
title_sort complexity of the cgas-sting pathway in cns pathologies
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900568/
https://www.ncbi.nlm.nih.gov/pubmed/33633536
http://dx.doi.org/10.3389/fnins.2021.621501
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