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The Complexity of the cGAS-STING Pathway in CNS Pathologies

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammatio...

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Detalles Bibliográficos
Autores principales: Fryer, Amelia L., Abdullah, Amar, Taylor, Juliet M., Crack, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900568/
https://www.ncbi.nlm.nih.gov/pubmed/33633536
http://dx.doi.org/10.3389/fnins.2021.621501