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The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
Coronavirus disease 2019 (COVID‐19) and pneumocystis pneumonia (PCP) share many overlapping features and may be clinically indistinguishable on initial presentation in people living with HIV. We present the case of co‐infection with COVID‐19 and PCP in a patient with progressive respiratory failure...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900711/ https://www.ncbi.nlm.nih.gov/pubmed/33664959 http://dx.doi.org/10.1002/rcr2.725 |
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author | Broadhurst, Alistair G.B. Lalla, Usha Taljaard, Jantjie J. Louw, Elizabeth H. Koegelenberg, Coenraad F.N. Allwood, Brian W. |
author_facet | Broadhurst, Alistair G.B. Lalla, Usha Taljaard, Jantjie J. Louw, Elizabeth H. Koegelenberg, Coenraad F.N. Allwood, Brian W. |
author_sort | Broadhurst, Alistair G.B. |
collection | PubMed |
description | Coronavirus disease 2019 (COVID‐19) and pneumocystis pneumonia (PCP) share many overlapping features and may be clinically indistinguishable on initial presentation in people living with HIV. We present the case of co‐infection with COVID‐19 and PCP in a patient with progressive respiratory failure admitted to our intensive care unit where the dominant disease was uncertain. This case highlights the difficulty in differentiating between the two diseases, especially in a high HIV prevalence setting where PCP is frequently diagnosed using case definitions and clinical experience due to limited access to bronchoscopy, appropriate laboratory testing, and computed tomography scans. In addition, diagnostic testing may yield false‐negative results in both diseases, and clinician awareness to the overlap and pitfalls is essential if COVID‐19 becomes endemic in such settings. |
format | Online Article Text |
id | pubmed-7900711 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-79007112021-03-03 The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV Broadhurst, Alistair G.B. Lalla, Usha Taljaard, Jantjie J. Louw, Elizabeth H. Koegelenberg, Coenraad F.N. Allwood, Brian W. Respirol Case Rep Case Reports Coronavirus disease 2019 (COVID‐19) and pneumocystis pneumonia (PCP) share many overlapping features and may be clinically indistinguishable on initial presentation in people living with HIV. We present the case of co‐infection with COVID‐19 and PCP in a patient with progressive respiratory failure admitted to our intensive care unit where the dominant disease was uncertain. This case highlights the difficulty in differentiating between the two diseases, especially in a high HIV prevalence setting where PCP is frequently diagnosed using case definitions and clinical experience due to limited access to bronchoscopy, appropriate laboratory testing, and computed tomography scans. In addition, diagnostic testing may yield false‐negative results in both diseases, and clinician awareness to the overlap and pitfalls is essential if COVID‐19 becomes endemic in such settings. John Wiley & Sons, Ltd 2021-02-22 /pmc/articles/PMC7900711/ /pubmed/33664959 http://dx.doi.org/10.1002/rcr2.725 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Reports Broadhurst, Alistair G.B. Lalla, Usha Taljaard, Jantjie J. Louw, Elizabeth H. Koegelenberg, Coenraad F.N. Allwood, Brian W. The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV |
title | The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
|
title_full | The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
|
title_fullStr | The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
|
title_full_unstemmed | The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
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title_short | The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
|
title_sort | diagnostic challenge of pneumocystis pneumonia and covid‐19 co‐infection in hiv |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900711/ https://www.ncbi.nlm.nih.gov/pubmed/33664959 http://dx.doi.org/10.1002/rcr2.725 |
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