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The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV

Coronavirus disease 2019 (COVID‐19) and pneumocystis pneumonia (PCP) share many overlapping features and may be clinically indistinguishable on initial presentation in people living with HIV. We present the case of co‐infection with COVID‐19 and PCP in a patient with progressive respiratory failure...

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Autores principales: Broadhurst, Alistair G.B., Lalla, Usha, Taljaard, Jantjie J., Louw, Elizabeth H., Koegelenberg, Coenraad F.N., Allwood, Brian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900711/
https://www.ncbi.nlm.nih.gov/pubmed/33664959
http://dx.doi.org/10.1002/rcr2.725
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author Broadhurst, Alistair G.B.
Lalla, Usha
Taljaard, Jantjie J.
Louw, Elizabeth H.
Koegelenberg, Coenraad F.N.
Allwood, Brian W.
author_facet Broadhurst, Alistair G.B.
Lalla, Usha
Taljaard, Jantjie J.
Louw, Elizabeth H.
Koegelenberg, Coenraad F.N.
Allwood, Brian W.
author_sort Broadhurst, Alistair G.B.
collection PubMed
description Coronavirus disease 2019 (COVID‐19) and pneumocystis pneumonia (PCP) share many overlapping features and may be clinically indistinguishable on initial presentation in people living with HIV. We present the case of co‐infection with COVID‐19 and PCP in a patient with progressive respiratory failure admitted to our intensive care unit where the dominant disease was uncertain. This case highlights the difficulty in differentiating between the two diseases, especially in a high HIV prevalence setting where PCP is frequently diagnosed using case definitions and clinical experience due to limited access to bronchoscopy, appropriate laboratory testing, and computed tomography scans. In addition, diagnostic testing may yield false‐negative results in both diseases, and clinician awareness to the overlap and pitfalls is essential if COVID‐19 becomes endemic in such settings.
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spelling pubmed-79007112021-03-03 The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV Broadhurst, Alistair G.B. Lalla, Usha Taljaard, Jantjie J. Louw, Elizabeth H. Koegelenberg, Coenraad F.N. Allwood, Brian W. Respirol Case Rep Case Reports Coronavirus disease 2019 (COVID‐19) and pneumocystis pneumonia (PCP) share many overlapping features and may be clinically indistinguishable on initial presentation in people living with HIV. We present the case of co‐infection with COVID‐19 and PCP in a patient with progressive respiratory failure admitted to our intensive care unit where the dominant disease was uncertain. This case highlights the difficulty in differentiating between the two diseases, especially in a high HIV prevalence setting where PCP is frequently diagnosed using case definitions and clinical experience due to limited access to bronchoscopy, appropriate laboratory testing, and computed tomography scans. In addition, diagnostic testing may yield false‐negative results in both diseases, and clinician awareness to the overlap and pitfalls is essential if COVID‐19 becomes endemic in such settings. John Wiley & Sons, Ltd 2021-02-22 /pmc/articles/PMC7900711/ /pubmed/33664959 http://dx.doi.org/10.1002/rcr2.725 Text en © 2021 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Broadhurst, Alistair G.B.
Lalla, Usha
Taljaard, Jantjie J.
Louw, Elizabeth H.
Koegelenberg, Coenraad F.N.
Allwood, Brian W.
The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
title The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
title_full The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
title_fullStr The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
title_full_unstemmed The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
title_short The diagnostic challenge of pneumocystis pneumonia and COVID‐19 co‐infection in HIV
title_sort diagnostic challenge of pneumocystis pneumonia and covid‐19 co‐infection in hiv
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900711/
https://www.ncbi.nlm.nih.gov/pubmed/33664959
http://dx.doi.org/10.1002/rcr2.725
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