Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

Inter-cellular heterogeneity in metabolic state has been proposed to influence many cancer phenotypes, including responses to targeted therapy. Here, we track the transitions and heritability of metabolic states in single PIK3CA mutant breast cancer cells, identify non-genetic glycolytic heterogenei...

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Detalles Bibliográficos
Autores principales: Kondo, Hiroshi, Ratcliffe, Colin D.H., Hooper, Steven, Ellis, James, MacRae, James I., Hennequart, Marc, Dunsby, Christopher W., Anderson, Kurt I., Sahai, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900713/
https://www.ncbi.nlm.nih.gov/pubmed/33596424
http://dx.doi.org/10.1016/j.celrep.2021.108750

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