Cargando…
Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study
PURPOSE: The purpose of this study was to determine systemic stressors, including fasting plasma glucose (FPG), and other major atherosclerotic cardiovascular disease (ASCVD) risk factors of the retinal microvasculature in people without diabetes. METHODS: The Kailuan Eye Study enrolled applicants f...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Association for Research in Vision and Ophthalmology
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900855/ https://www.ncbi.nlm.nih.gov/pubmed/33595612 http://dx.doi.org/10.1167/iovs.62.2.20 |
_version_ | 1783654293837971456 |
---|---|
author | Zhou, Wenjia Yang, Jingyan Wang, Qian Wang, Yaxing Yan, Yanni Wu, Shouling Chen, Shuohua Wei, Wenbin |
author_facet | Zhou, Wenjia Yang, Jingyan Wang, Qian Wang, Yaxing Yan, Yanni Wu, Shouling Chen, Shuohua Wei, Wenbin |
author_sort | Zhou, Wenjia |
collection | PubMed |
description | PURPOSE: The purpose of this study was to determine systemic stressors, including fasting plasma glucose (FPG), and other major atherosclerotic cardiovascular disease (ASCVD) risk factors of the retinal microvasculature in people without diabetes. METHODS: The Kailuan Eye Study enrolled applicants from the community-based longitudinal Kailuan Study. Applicants underwent optical coherence tomographic angiography (OCTA) and systemic examinations. Both the macula and optic disc were screened, whereas superficial capillary plexus (SCP), deep capillary plexus (DCP), foveal vessel density in the 300 µm ring (FD-300), and radial peripapillary capillaries (RPCs) density were measured in the study. RESULTS: This study included 353 eligible applicants (mean age = 49.86 ± 11.41 years; 47% men; FPG =5.32 ± 1.19 mmol/L). Lower DCP density was associated with elder age (P = 0.001), male gender (P < 0.001), and higher FPG (P = 0.008). Male gender (P < 0.001), axial length (P < 0.001), and FPG (P = 0.029) were inversely associated with RPC density. Meanwhile, a higher FPG concentration was significantly correlated with lower DCP density (P = 0.006) and higher intraocular pressure (P = 0.006), after adjusting mean arterial blood pressure (P = 0.001) and sex (P = 0.042). CONCLUSIONS: DCP density showed a significantly negative correlation with FPG concentration in people without diabetes. These data suggest hyperglycemia could cause early retinal capillary alterations in patients without clinical signs of retinopathy and indicate the potential clinical applications of routine OCTA may be beneficial to screen for subclinical microvasculature and monitor patients with high risks of ASCVD. |
format | Online Article Text |
id | pubmed-7900855 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Association for Research in Vision and Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-79008552021-03-03 Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study Zhou, Wenjia Yang, Jingyan Wang, Qian Wang, Yaxing Yan, Yanni Wu, Shouling Chen, Shuohua Wei, Wenbin Invest Ophthalmol Vis Sci Retina PURPOSE: The purpose of this study was to determine systemic stressors, including fasting plasma glucose (FPG), and other major atherosclerotic cardiovascular disease (ASCVD) risk factors of the retinal microvasculature in people without diabetes. METHODS: The Kailuan Eye Study enrolled applicants from the community-based longitudinal Kailuan Study. Applicants underwent optical coherence tomographic angiography (OCTA) and systemic examinations. Both the macula and optic disc were screened, whereas superficial capillary plexus (SCP), deep capillary plexus (DCP), foveal vessel density in the 300 µm ring (FD-300), and radial peripapillary capillaries (RPCs) density were measured in the study. RESULTS: This study included 353 eligible applicants (mean age = 49.86 ± 11.41 years; 47% men; FPG =5.32 ± 1.19 mmol/L). Lower DCP density was associated with elder age (P = 0.001), male gender (P < 0.001), and higher FPG (P = 0.008). Male gender (P < 0.001), axial length (P < 0.001), and FPG (P = 0.029) were inversely associated with RPC density. Meanwhile, a higher FPG concentration was significantly correlated with lower DCP density (P = 0.006) and higher intraocular pressure (P = 0.006), after adjusting mean arterial blood pressure (P = 0.001) and sex (P = 0.042). CONCLUSIONS: DCP density showed a significantly negative correlation with FPG concentration in people without diabetes. These data suggest hyperglycemia could cause early retinal capillary alterations in patients without clinical signs of retinopathy and indicate the potential clinical applications of routine OCTA may be beneficial to screen for subclinical microvasculature and monitor patients with high risks of ASCVD. The Association for Research in Vision and Ophthalmology 2021-02-17 /pmc/articles/PMC7900855/ /pubmed/33595612 http://dx.doi.org/10.1167/iovs.62.2.20 Text en Copyright 2021 The Authors http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. |
spellingShingle | Retina Zhou, Wenjia Yang, Jingyan Wang, Qian Wang, Yaxing Yan, Yanni Wu, Shouling Chen, Shuohua Wei, Wenbin Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study |
title | Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study |
title_full | Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study |
title_fullStr | Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study |
title_full_unstemmed | Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study |
title_short | Systemic Stressors and Retinal Microvascular Alterations in People Without Diabetes: The Kailuan Eye Study |
title_sort | systemic stressors and retinal microvascular alterations in people without diabetes: the kailuan eye study |
topic | Retina |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7900855/ https://www.ncbi.nlm.nih.gov/pubmed/33595612 http://dx.doi.org/10.1167/iovs.62.2.20 |
work_keys_str_mv | AT zhouwenjia systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT yangjingyan systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT wangqian systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT wangyaxing systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT yanyanni systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT wushouling systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT chenshuohua systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy AT weiwenbin systemicstressorsandretinalmicrovascularalterationsinpeoplewithoutdiabetesthekailuaneyestudy |