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Helicobacter pylori: Commensal, symbiont or pathogen?
This review considers the data on Helicobacter pylori (H. pylori), which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901052/ https://www.ncbi.nlm.nih.gov/pubmed/33642828 http://dx.doi.org/10.3748/wjg.v27.i7.545 |
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author | Reshetnyak, Vasiliy Ivanovich Burmistrov, Alexandr Igorevich Maev, Igor Veniaminovich |
author_facet | Reshetnyak, Vasiliy Ivanovich Burmistrov, Alexandr Igorevich Maev, Igor Veniaminovich |
author_sort | Reshetnyak, Vasiliy Ivanovich |
collection | PubMed |
description | This review considers the data on Helicobacter pylori (H. pylori), which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis, peptic ulcer disease, and gastric cancer, as well as methods for its eradication. However, in recent years, there have been more and more studies which have suggested that H. pylori has a beneficial, or potentially positive, effect on the human body. The authors have attempted to objectively analyze the information accumulated in the literature on H. pylori. Some studies consider it as one of the recently identified human bacterial pathogens, and special attention is paid to the evidence suggesting that it is probably part of the composition of the human microbiome as a commensal (commensal from French to English is a table companion) or even a symbiont. The presented data discussing the presence or absence of the effect of H. pylori on human health suggest that there is an apparent ambiguity of the problem. The re-assessment of the data available on H. pylori infection is important in order to answer the question of whether it is necessary to create a program of mass H. pylori eradication or to apply a more personalized approach to treating patients with H. pylori-associated gastrointestinal diseases and to perform eradication therapy. |
format | Online Article Text |
id | pubmed-7901052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-79010522021-02-26 Helicobacter pylori: Commensal, symbiont or pathogen? Reshetnyak, Vasiliy Ivanovich Burmistrov, Alexandr Igorevich Maev, Igor Veniaminovich World J Gastroenterol Review This review considers the data on Helicobacter pylori (H. pylori), which have been accumulated over 40 years since its description as an etiological factor in gastrointestinal diseases. The majority of modern publications are devoted to the study of the pathogenic properties of the microorganism in the development of chronic gastritis, peptic ulcer disease, and gastric cancer, as well as methods for its eradication. However, in recent years, there have been more and more studies which have suggested that H. pylori has a beneficial, or potentially positive, effect on the human body. The authors have attempted to objectively analyze the information accumulated in the literature on H. pylori. Some studies consider it as one of the recently identified human bacterial pathogens, and special attention is paid to the evidence suggesting that it is probably part of the composition of the human microbiome as a commensal (commensal from French to English is a table companion) or even a symbiont. The presented data discussing the presence or absence of the effect of H. pylori on human health suggest that there is an apparent ambiguity of the problem. The re-assessment of the data available on H. pylori infection is important in order to answer the question of whether it is necessary to create a program of mass H. pylori eradication or to apply a more personalized approach to treating patients with H. pylori-associated gastrointestinal diseases and to perform eradication therapy. Baishideng Publishing Group Inc 2021-02-21 2021-02-21 /pmc/articles/PMC7901052/ /pubmed/33642828 http://dx.doi.org/10.3748/wjg.v27.i7.545 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
spellingShingle | Review Reshetnyak, Vasiliy Ivanovich Burmistrov, Alexandr Igorevich Maev, Igor Veniaminovich Helicobacter pylori: Commensal, symbiont or pathogen? |
title |
Helicobacter pylori: Commensal, symbiont or pathogen? |
title_full |
Helicobacter pylori: Commensal, symbiont or pathogen? |
title_fullStr |
Helicobacter pylori: Commensal, symbiont or pathogen? |
title_full_unstemmed |
Helicobacter pylori: Commensal, symbiont or pathogen? |
title_short |
Helicobacter pylori: Commensal, symbiont or pathogen? |
title_sort | helicobacter pylori: commensal, symbiont or pathogen? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901052/ https://www.ncbi.nlm.nih.gov/pubmed/33642828 http://dx.doi.org/10.3748/wjg.v27.i7.545 |
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