High nuclear TPX2 expression correlates with TP53 mutation and poor clinical behavior in a large breast cancer cohort, but is not an independent predictor of chromosomal instability

BACKGROUND: Targeting Protein for Xenopus Kinesin Like Protein 2 (TPX2) is a microtubule associated protein that functions in mitotic spindle assembly. TPX2 also localizes to the nucleus where it functions in DNA damage repair during S-phase. We and others have previously shown that TPX2 RNA levels...

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Detalles Bibliográficos
Autores principales: Matson, Daniel R., Denu, Ryan A., Zasadil, Lauren M., Burkard, Mark E., Weaver, Beth A., Flynn, Christopher, Stukenberg, P. Todd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901195/
https://www.ncbi.nlm.nih.gov/pubmed/33622270
http://dx.doi.org/10.1186/s12885-021-07893-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901195/
https://www.ncbi.nlm.nih.gov/pubmed/33622270
http://dx.doi.org/10.1186/s12885-021-07893-7

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