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Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19

The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no approved drugs targeting the regulatory p...

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Autores principales: Qin, Zhen, Xiang, Kefa, Su, Ding-Feng, Sun, Yang, Liu, Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901247/
https://www.ncbi.nlm.nih.gov/pubmed/33633726
http://dx.doi.org/10.3389/fimmu.2020.595342
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author Qin, Zhen
Xiang, Kefa
Su, Ding-Feng
Sun, Yang
Liu, Xia
author_facet Qin, Zhen
Xiang, Kefa
Su, Ding-Feng
Sun, Yang
Liu, Xia
author_sort Qin, Zhen
collection PubMed
description The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no approved drugs targeting the regulatory pathway. It is evident that nicotine, anisodamine and some herb medicine, activate the CAP and exert anti-inflammation action in vitro and in vivo. As the vagus nerve affects both inflammation and specific immune response, we propose that vagus nerve stimulation by invasive or non-invasive devices and acupuncture at ST36, PC6, or GV20, are also feasible approaches to activate the CAP and control COVID-19. It is worth to investigate the efficacy and safety of the strategy in patients with COVID-19.
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spelling pubmed-79012472021-02-24 Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19 Qin, Zhen Xiang, Kefa Su, Ding-Feng Sun, Yang Liu, Xia Front Immunol Immunology The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no approved drugs targeting the regulatory pathway. It is evident that nicotine, anisodamine and some herb medicine, activate the CAP and exert anti-inflammation action in vitro and in vivo. As the vagus nerve affects both inflammation and specific immune response, we propose that vagus nerve stimulation by invasive or non-invasive devices and acupuncture at ST36, PC6, or GV20, are also feasible approaches to activate the CAP and control COVID-19. It is worth to investigate the efficacy and safety of the strategy in patients with COVID-19. Frontiers Media S.A. 2021-02-08 /pmc/articles/PMC7901247/ /pubmed/33633726 http://dx.doi.org/10.3389/fimmu.2020.595342 Text en Copyright © 2021 Qin, Xiang, Su, Sun and Liu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Qin, Zhen
Xiang, Kefa
Su, Ding-Feng
Sun, Yang
Liu, Xia
Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
title Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
title_full Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
title_fullStr Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
title_full_unstemmed Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
title_short Activation of the Cholinergic Anti-Inflammatory Pathway as a Novel Therapeutic Strategy for COVID-19
title_sort activation of the cholinergic anti-inflammatory pathway as a novel therapeutic strategy for covid-19
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901247/
https://www.ncbi.nlm.nih.gov/pubmed/33633726
http://dx.doi.org/10.3389/fimmu.2020.595342
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