A trans-complementation system for SARS-CoV-2 recapitulates authentic viral replication without virulence

The biosafety level 3 (BSL-3) requirement to culture severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a bottleneck for research. Here, we report a trans-complementation system that produces single-round infectious SARS-CoV-2 that recapitulates authentic viral replication. We demonstra...

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Detalles Bibliográficos
Autores principales: Zhang, Xianwen, Liu, Yang, Liu, Jianying, Bailey, Adam L., Plante, Kenneth S., Plante, Jessica A., Zou, Jing, Xia, Hongjie, Bopp, Nathen E., Aguilar, Patricia V., Ren, Ping, Menachery, Vineet D., Diamond, Michael S., Weaver, Scott C., Xie, Xuping, Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Resource
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901297/
https://www.ncbi.nlm.nih.gov/pubmed/33691138
http://dx.doi.org/10.1016/j.cell.2021.02.044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901297/
https://www.ncbi.nlm.nih.gov/pubmed/33691138
http://dx.doi.org/10.1016/j.cell.2021.02.044

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