Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients

Programmed death 1(PD-1) blockade has shown promising efficacy in advanced gastric cancer. Here, we performed a retrospective analysis of three patients with locally advanced gastric cancer who received adjuvant PD-1 plus chemoradiotherapy as neoadjuvant treatment. Neoadjuvant sintilimab plus concur...

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Autores principales: Wei, Jia, Lu, Xiaofeng, Liu, Qin, Li, Lin, Liu, Song, Liu, Fangcen, Fu, Yao, Fan, Xiangshan, Yang, Yang, Qi, Chuang, Yu, Yangyang, Guan, Wenxian, Liu, Baorui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901487/
https://www.ncbi.nlm.nih.gov/pubmed/33634011
http://dx.doi.org/10.3389/fonc.2020.554040
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author Wei, Jia
Lu, Xiaofeng
Liu, Qin
Li, Lin
Liu, Song
Liu, Fangcen
Fu, Yao
Fan, Xiangshan
Yang, Yang
Qi, Chuang
Yu, Yangyang
Guan, Wenxian
Liu, Baorui
author_facet Wei, Jia
Lu, Xiaofeng
Liu, Qin
Li, Lin
Liu, Song
Liu, Fangcen
Fu, Yao
Fan, Xiangshan
Yang, Yang
Qi, Chuang
Yu, Yangyang
Guan, Wenxian
Liu, Baorui
author_sort Wei, Jia
collection PubMed
description Programmed death 1(PD-1) blockade has shown promising efficacy in advanced gastric cancer. Here, we performed a retrospective analysis of three patients with locally advanced gastric cancer who received adjuvant PD-1 plus chemoradiotherapy as neoadjuvant treatment. Neoadjuvant sintilimab plus concurrent chemoradiotherapy had an acceptable side-effect profile. All three patients underwent surgical gastrectomy after a median of 3.9 months. A major pathological response occurred in two resected tumors and a pathologic complete response was observed in one patient. Our results suggest that PD-1 blockade combined with chemoradiotherapy is a promising strategy as a neoadjuvant therapy in patients with unresectable locally advanced gastric cancer.
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spelling pubmed-79014872021-02-24 Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients Wei, Jia Lu, Xiaofeng Liu, Qin Li, Lin Liu, Song Liu, Fangcen Fu, Yao Fan, Xiangshan Yang, Yang Qi, Chuang Yu, Yangyang Guan, Wenxian Liu, Baorui Front Oncol Oncology Programmed death 1(PD-1) blockade has shown promising efficacy in advanced gastric cancer. Here, we performed a retrospective analysis of three patients with locally advanced gastric cancer who received adjuvant PD-1 plus chemoradiotherapy as neoadjuvant treatment. Neoadjuvant sintilimab plus concurrent chemoradiotherapy had an acceptable side-effect profile. All three patients underwent surgical gastrectomy after a median of 3.9 months. A major pathological response occurred in two resected tumors and a pathologic complete response was observed in one patient. Our results suggest that PD-1 blockade combined with chemoradiotherapy is a promising strategy as a neoadjuvant therapy in patients with unresectable locally advanced gastric cancer. Frontiers Media S.A. 2021-02-05 /pmc/articles/PMC7901487/ /pubmed/33634011 http://dx.doi.org/10.3389/fonc.2020.554040 Text en Copyright © 2021 Wei, Lu, Liu, Li, Liu, Liu, Fu, Fan, Yang, Qi, Yu, Guan and Liu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wei, Jia
Lu, Xiaofeng
Liu, Qin
Li, Lin
Liu, Song
Liu, Fangcen
Fu, Yao
Fan, Xiangshan
Yang, Yang
Qi, Chuang
Yu, Yangyang
Guan, Wenxian
Liu, Baorui
Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients
title Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients
title_full Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients
title_fullStr Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients
title_full_unstemmed Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients
title_short Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients
title_sort case report: neoadjuvant pd-1 blockade plus concurrent chemoradiotherapy in unresectable locally advanced gastric cancer patients
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901487/
https://www.ncbi.nlm.nih.gov/pubmed/33634011
http://dx.doi.org/10.3389/fonc.2020.554040
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