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Full Activation of Kinase Protein Kinase B by Phosphoinositide-Dependent Protein Kinase-1 and Mammalian Target of Rapamycin Complex 2 Is Required for Early Natural Killer Cell Development and Survival

The role of PI3K-mTOR pathway in regulating NK cell development has been widely reported. However, it remains unclear whether NK cell development depends on the protein kinase B (PKB), which links PI3K and mTOR, perhaps due to the potential redundancy of PKB. PKB has two phosphorylation sites, threo...

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Detalles Bibliográficos
Autores principales:	He, Junming, Zhao, Jun, Quan, Yuhe, Hou, Xinlei, Yang, Meixiang, Dong, Zhongjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901528/ https://www.ncbi.nlm.nih.gov/pubmed/33633735 http://dx.doi.org/10.3389/fimmu.2020.617404

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