Cargando…

Development of a Solid Supersaturable Micelle of Revaprazan for Improved Dissolution and Oral Bioavailability Using Box-Behnken Design

PURPOSE: To enhance the oral bioavailability of revaprazan (RVP), a novel solid, supersaturable micelle (SSuM) was developed. METHODS: Surfactants and solid carriers were screened based on a solubility and a flowability test, respectively. Supersaturating agents, including Poloxamer 407 (P407), were...

Descripción completa

Detalles Bibliográficos
Autores principales:	Goo, Yoon Tae, Sa, Cheol-Ki, Choi, Ji Yeh, Kim, Min Song, Kim, Chang Hyun, Kim, Hyeon Kyun, Choi, Young Wook
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901570/ https://www.ncbi.nlm.nih.gov/pubmed/33633449 http://dx.doi.org/10.2147/IJN.S298450

Ejemplares similares

Solid formulation of a supersaturable self-microemulsifying drug delivery system for valsartan with improved dissolution and bioavailability
por: Yeom, Dong Woo, et al.
Publicado: (2017)

Improved Dissolution and Oral Bioavailability of Valsartan Using a Solidified Supersaturable Self-Microemulsifying Drug Delivery System Containing Gelucire(®) 44/14
por: Shin, Dong Jun, et al.
Publicado: (2019)

Spray-Dried Amorphous Solid Dispersions of Atorvastatin Calcium for Improved Supersaturation and Oral Bioavailability
por: Kwon, Jaewook, et al.
Publicado: (2019)

Nanoseeded Desupersaturation and Dissolution Tests for Elucidating Supersaturation Maintenance in Amorphous Solid Dispersions
por: Guner, Gulenay, et al.
Publicado: (2023)

Enhanced dissolution and oral absorption of tacrolimus by supersaturable self-emulsifying drug delivery system
por: Lee, Dae Ro, et al.
Publicado: (2016)

A Polyvinylpyrrolidone-Based Supersaturable Self-Emulsifying Drug Delivery System for Enhanced Dissolution of Cyclosporine A
por: Lee, Dae Ro, et al.
Publicado: (2017)

Supersaturable solid self-microemulsifying drug delivery system: precipitation inhibition and bioavailability enhancement
por: Quan, Guilan, et al.
Publicado: (2017)

Roles of effective stabilizers in improving oral bioavailability of naringenin nanocrystals: Maintenance of supersaturation generated upon dissolution by inhibition of drug dimerization
por: Zhang, Guangshuai, et al.
Publicado: (2022)

Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system
por: Yeom, Dong Woo, et al.
Publicado: (2017)

Influence of hydrophilic additives on the supersaturation and bioavailability of dutasteride-loaded hydroxypropyl-β-cyclodextrin nanostructures
por: Kim, Min-Soo
Publicado: (2013)

Boosting Tadalafil Bioavailability via Sono-Assisted Nano-Emulsion-Based Oral Jellies: Box–Behnken Optimization and Assessment
por: Ali, Hany S. M., et al.
Publicado: (2022)

Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax
por: Koehl, Niklas J., et al.
Publicado: (2020)

Flurbiprofen-Loaded Solid SNEDDS Preconcentrate for the Enhanced Solubility, In-Vitro Dissolution and Bioavailability in Rats
por: Kim, Rae Man, et al.
Publicado: (2018)

Cefdinir Solid Dispersion Composed of Hydrophilic Polymers with Enhanced Solubility, Dissolution, and Bioavailability in Rats
por: Cho, Hyun-Jong, et al.
Publicado: (2017)

Supersaturated polymeric micelles for oral silybin delivery: the role of the Soluplus–PVPVA complex
por: Zhu, Chunliu, et al.
Publicado: (2019)

Preparation, Statistical Optimization and Characterization of Propolis-Loaded Solid Lipid Nanoparticles Using Box-Behnken Design
por: Taherzadeh, Sahar, et al.
Publicado: (2021)

Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals
por: Feng, Yumiao, et al.
Publicado: (2021)

Formulation and characterization of ketoprofen liquisolid compacts by Box-Behnken design
por: Vittal, G Vijayaranga, et al.
Publicado: (2012)

The application of Box-Behnken-Design in the optimization of HPLC separation of fluoroquinolones
por: Czyrski, Andrzej, et al.
Publicado: (2019)

Synthesis of Polyhydroxyurethanes—Experimental Verification of the Box–Behnken Optimization Model
por: Zalewski, Michał J., et al.
Publicado: (2022)

Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design
por: Kim, Min-Hwan, et al.
Publicado: (2019)

Tri-block polymer with interfacial layer formation ability and its use in maintaining supersaturated drug solution after dissolution of solid dispersions
por: Fu, Ji-Jun, et al.
Publicado: (2018)

Supersaturation as a Galenic Concept for Improving the Cutaneous Bioavailability of Drugs in Topical Therapy
por: Wohlrab, Johannes, et al.
Publicado: (2022)

Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design
por: Hao, Jifu, et al.
Publicado: (2011)

Formulation and optimization of solid lipid nanoparticle formulation for pulmonary delivery of budesonide using Taguchi and Box-Behnken design
por: Emami, J., et al.
Publicado: (2015)

Rheological and Mechanical Analyses of Felbinac Cataplasms by Using Box–Behnken Design
por: Yang, Jie, et al.
Publicado: (2018)

Sorption studies of europium on cerium phosphate using Box-Behnken design
por: İNAN, Süleyman
Publicado: (2020)

Box–Behnken Design for Polycarbonate-Pigment Blending: Applications and Characterization Techniques
por: Alsadi, Jamal, et al.
Publicado: (2022)

Box–Behnken Design of Experiments of Polycaprolactone Nanoparticles Loaded with Irinotecan Hydrochloride
por: Mahmoud, Basant Salah, et al.
Publicado: (2023)

Optimization of the Poly(glycerol citraconate) Synthesis Using the Box–Behnken Design
por: Kolankowski, Krzysztof, et al.
Publicado: (2023)

Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization
por: Ha, Eun-Sol, et al.
Publicado: (2015)

Revaprazan, a novel acid pump antagonist, exerts anti-inflammatory action against Helicobacter pylori-induced COX-2 expression by inactivating Akt signaling
por: Lee, Jeong-Sang, et al.
Publicado: (2012)

Dissolution and bioavailability improvement of bioactive apigenin using solid dispersions prepared by different techniques
por: Alshehri, Sultan M., et al.
Publicado: (2019)

Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry
por: Zhang, Qihong, et al.
Publicado: (2018)

Statistical optimization of tetrahydrocurcumin loaded solid lipid nanoparticles using Box Behnken design in the management of streptozotocin-induced diabetes mellitus
por: Bharti Sharma, Jai, et al.
Publicado: (2023)

Optimizing Operating Parameters of High-Temperature Steam for Disinfecting Total Nematodes and Bacteria in Soil: Application of the Box–Behnken Design
por: Huh, Da-An, et al.
Publicado: (2020)

Formulation and Optimization of Oral Mucoadhesive Patches of Myrtus Communis by Box Behnken Design
por: Hashemi, Mahbubeh, et al.
Publicado: (2017)

Application of Box-Behnken Design in Production of Monoglyceride with Esterification of Glycerol and Oleic Acid
por: Neji, Soumaya Bouguerra, et al.
Publicado: (2023)

Supersaturation-Based Drug Delivery Systems: Strategy for Bioavailability Enhancement of Poorly Water-Soluble Drugs
por: Sharma, Arvind, et al.
Publicado: (2022)

Functional Fragments of AIMP1-Derived Peptide (AdP) and Optimized Hydrosol for Their Topical Deposition by Box-Behnken Design
por: Lee, Jeong-Jun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lt3v5g6mqp2snjchh01qc93ru0