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A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide

R-loops are three-stranded nucleic acid structures with essential roles in many nuclear processes. However, their unchecked accumulation is associated with genome instability and is observed in neurodevelopmental diseases and cancers. Genome-wide profiling of R-loops in normal and diseased cells can...

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Detalles Bibliográficos
Autores principales: Wulfridge, Phillip, Sarma, Kavitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901872/
https://www.ncbi.nlm.nih.gov/pubmed/33620319
http://dx.doi.org/10.7554/eLife.65146