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A nuclease- and bisulfite-based strategy captures strand-specific R-loops genome-wide
R-loops are three-stranded nucleic acid structures with essential roles in many nuclear processes. However, their unchecked accumulation is associated with genome instability and is observed in neurodevelopmental diseases and cancers. Genome-wide profiling of R-loops in normal and diseased cells can...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901872/ https://www.ncbi.nlm.nih.gov/pubmed/33620319 http://dx.doi.org/10.7554/eLife.65146 |