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Human Ubiquitin-Specific Peptidase 18 Is Regulated by microRNAs via the 3'Untranslated Region, A Sequence Duplicated in Long Intergenic Non-coding RNA Genes Residing in chr22q11.21

Ubiquitin-specific peptidase 18 (USP18) acts as gatekeeper of type I interferon (IFN) responses by binding to the IFN receptor subunit IFNAR2 and preventing activation of the downstream JAK/STAT pathway. In any given cell type, the level of USP18 is a key determinant of the output of IFN-stimulated...

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Detalles Bibliográficos
Autores principales:	Rubino, Erminia, Cruciani, Melania, Tchitchek, Nicolas, Le Tortorec, Anna, Rolland, Antoine D., Veli, Önay, Vallet, Leslie, Gaggi, Giulia, Michel, Frédérique, Dejucq-Rainsford, Nathalie, Pellegrini, Sandra
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901961/ https://www.ncbi.nlm.nih.gov/pubmed/33633774 http://dx.doi.org/10.3389/fgene.2020.627007

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