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Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis

Purpose: Exercise training reveals high potential to beneficially impact cognitive performance in persons with multiple sclerosis (pwMS). Research indicates that high-intensity interval training (HIIT) has potentially higher effects on physical fitness and cognition compared to moderate continuous e...

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Autores principales: Rademacher, Annette, Joisten, Niklas, Proschinger, Sebastian, Bloch, Wilhelm, Gonzenbach, Roman, Kool, Jan, Langdon, Dawn, Bansi, Jens, Zimmer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902024/
https://www.ncbi.nlm.nih.gov/pubmed/33633658
http://dx.doi.org/10.3389/fneur.2020.619500
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author Rademacher, Annette
Joisten, Niklas
Proschinger, Sebastian
Bloch, Wilhelm
Gonzenbach, Roman
Kool, Jan
Langdon, Dawn
Bansi, Jens
Zimmer, Philipp
author_facet Rademacher, Annette
Joisten, Niklas
Proschinger, Sebastian
Bloch, Wilhelm
Gonzenbach, Roman
Kool, Jan
Langdon, Dawn
Bansi, Jens
Zimmer, Philipp
author_sort Rademacher, Annette
collection PubMed
description Purpose: Exercise training reveals high potential to beneficially impact cognitive performance in persons with multiple sclerosis (pwMS). Research indicates that high-intensity interval training (HIIT) has potentially higher effects on physical fitness and cognition compared to moderate continuous exercise. This study (i) compares the effects of a 3-week HIIT and moderate continuous exercise training on cognitive performance and cardiorespiratory fitness of pwMS in an overall analysis and (ii) investigates potential effects based on baseline cognitive status in a subgroup analysis. Methods: Seventy-five pwMS were randomly assigned to an intervention (HIIT: 5 × 1.5-min intervals at 95–100% HR(max), 3 ×/week) or active control group (CG: 24 min continuous exercise at 65% HR(max), 3 ×/week). Cognitive performance was assessed pre- and post-intervention with the Brief International Cognitive Assessment for MS (BICAMS). (I) To examine potential within (time) and interaction (time × group) effects in the overall analysis, separate analyses of covariance (ANCOVA) were conducted. (II) For the subgroup analysis, participants were divided into two groups [intact cognition or impaired cognition (>1.5 standard deviation (SD) compared to healthy, age-matched norm data in at least one of the three tests of the BICAMS]. Potential impacts of cognitive status and intervention were investigated with multivariate analyses of variance (MANOVA). Results: Overall analysis revealed significant time effects for processing speed, verbal learning, rel. VO2peak, and rel. power output. A time(*)group interaction effect was observed for rel. power output. Subgroup analysis indicated a significant main effect for cognition (impaired cognition vs. intact cognition). Subsequent post-hoc analysis showed significant larger effects on verbal learning in pwMS with impaired cognition. Conclusion: Current results need to be confirmed in a powered randomized controlled trial with cognitive performance as primary endpoint and eligibility based on cognitive performance that is assessed prior to study inclusion.
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spelling pubmed-79020242021-02-24 Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis Rademacher, Annette Joisten, Niklas Proschinger, Sebastian Bloch, Wilhelm Gonzenbach, Roman Kool, Jan Langdon, Dawn Bansi, Jens Zimmer, Philipp Front Neurol Neurology Purpose: Exercise training reveals high potential to beneficially impact cognitive performance in persons with multiple sclerosis (pwMS). Research indicates that high-intensity interval training (HIIT) has potentially higher effects on physical fitness and cognition compared to moderate continuous exercise. This study (i) compares the effects of a 3-week HIIT and moderate continuous exercise training on cognitive performance and cardiorespiratory fitness of pwMS in an overall analysis and (ii) investigates potential effects based on baseline cognitive status in a subgroup analysis. Methods: Seventy-five pwMS were randomly assigned to an intervention (HIIT: 5 × 1.5-min intervals at 95–100% HR(max), 3 ×/week) or active control group (CG: 24 min continuous exercise at 65% HR(max), 3 ×/week). Cognitive performance was assessed pre- and post-intervention with the Brief International Cognitive Assessment for MS (BICAMS). (I) To examine potential within (time) and interaction (time × group) effects in the overall analysis, separate analyses of covariance (ANCOVA) were conducted. (II) For the subgroup analysis, participants were divided into two groups [intact cognition or impaired cognition (>1.5 standard deviation (SD) compared to healthy, age-matched norm data in at least one of the three tests of the BICAMS]. Potential impacts of cognitive status and intervention were investigated with multivariate analyses of variance (MANOVA). Results: Overall analysis revealed significant time effects for processing speed, verbal learning, rel. VO2peak, and rel. power output. A time(*)group interaction effect was observed for rel. power output. Subgroup analysis indicated a significant main effect for cognition (impaired cognition vs. intact cognition). Subsequent post-hoc analysis showed significant larger effects on verbal learning in pwMS with impaired cognition. Conclusion: Current results need to be confirmed in a powered randomized controlled trial with cognitive performance as primary endpoint and eligibility based on cognitive performance that is assessed prior to study inclusion. Frontiers Media S.A. 2021-01-28 /pmc/articles/PMC7902024/ /pubmed/33633658 http://dx.doi.org/10.3389/fneur.2020.619500 Text en Copyright © 2021 Rademacher, Joisten, Proschinger, Bloch, Gonzenbach, Kool, Langdon, Bansi and Zimmer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Rademacher, Annette
Joisten, Niklas
Proschinger, Sebastian
Bloch, Wilhelm
Gonzenbach, Roman
Kool, Jan
Langdon, Dawn
Bansi, Jens
Zimmer, Philipp
Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
title Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
title_full Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
title_fullStr Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
title_full_unstemmed Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
title_short Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis
title_sort cognitive impairment impacts exercise effects on cognition in multiple sclerosis
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902024/
https://www.ncbi.nlm.nih.gov/pubmed/33633658
http://dx.doi.org/10.3389/fneur.2020.619500
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