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Percutaneous application of allogeneic adipose-derived mesenchymal stem cell in dogs submitted to minimally invasive plate osteosynthesis of the tibia
PURPOSE: To evaluate clinical outcome following minimally invasive plate osteosynthesis (MIPO) associated with percutaneous transplantation of allogeneic adipose-derived mesenchymal stem cells (AD-MSC) at the tibial fracture site in dogs. METHODS: Thirty-six dogs presenting with nonarticular complet...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira para o Desenvolvimento da Pesquisa em
Cirurgia
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902052/ https://www.ncbi.nlm.nih.gov/pubmed/33624723 http://dx.doi.org/10.1590/ACB360206 |
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author | Franco, Guilherme Galhardo Minto, Bruno Watanabe Dreibi, Rafael Manzini Costa, Jose Sergio Dias, Luis Gustavo Gosuen Gonçalves |
author_facet | Franco, Guilherme Galhardo Minto, Bruno Watanabe Dreibi, Rafael Manzini Costa, Jose Sergio Dias, Luis Gustavo Gosuen Gonçalves |
author_sort | Franco, Guilherme Galhardo |
collection | PubMed |
description | PURPOSE: To evaluate clinical outcome following minimally invasive plate osteosynthesis (MIPO) associated with percutaneous transplantation of allogeneic adipose-derived mesenchymal stem cells (AD-MSC) at the tibial fracture site in dogs. METHODS: Thirty-six dogs presenting with nonarticular complete tibial fracture were included in this study. All fractures were treated by the same MIPO technique. The animals were divided in group 1 (n = 20) received a percutaneous application of 3 × 10(6) AD-MSC at the fracture site and group 2 (n = 16) did not receive any adjuvant treatment. Postoperative radiographic examinations were made at 15, 30, 60, 90 and 120 days. RESULTS: Fifty-eight percent of the patients were classified as skeletally immature. The median weight of the animals was 18.8 kg. The mean radiographic union time differed statistically between the AD-MSC group (28.5 days) and the control group (70.3 days). Sixty percent of dogs in group 1 and 56.25% of the group 2 were considered immature. CONCLUSIONS: The use of allogeneic AD-MSC cell therapy and MIPO is a safe, viable and effective technique for promoting bone healing in nonarticular tibial fractures in dogs. |
format | Online Article Text |
id | pubmed-7902052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em
Cirurgia |
record_format | MEDLINE/PubMed |
spelling | pubmed-79020522021-03-04 Percutaneous application of allogeneic adipose-derived mesenchymal stem cell in dogs submitted to minimally invasive plate osteosynthesis of the tibia Franco, Guilherme Galhardo Minto, Bruno Watanabe Dreibi, Rafael Manzini Costa, Jose Sergio Dias, Luis Gustavo Gosuen Gonçalves Acta Cir Bras Original Article PURPOSE: To evaluate clinical outcome following minimally invasive plate osteosynthesis (MIPO) associated with percutaneous transplantation of allogeneic adipose-derived mesenchymal stem cells (AD-MSC) at the tibial fracture site in dogs. METHODS: Thirty-six dogs presenting with nonarticular complete tibial fracture were included in this study. All fractures were treated by the same MIPO technique. The animals were divided in group 1 (n = 20) received a percutaneous application of 3 × 10(6) AD-MSC at the fracture site and group 2 (n = 16) did not receive any adjuvant treatment. Postoperative radiographic examinations were made at 15, 30, 60, 90 and 120 days. RESULTS: Fifty-eight percent of the patients were classified as skeletally immature. The median weight of the animals was 18.8 kg. The mean radiographic union time differed statistically between the AD-MSC group (28.5 days) and the control group (70.3 days). Sixty percent of dogs in group 1 and 56.25% of the group 2 were considered immature. CONCLUSIONS: The use of allogeneic AD-MSC cell therapy and MIPO is a safe, viable and effective technique for promoting bone healing in nonarticular tibial fractures in dogs. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2021-02-22 /pmc/articles/PMC7902052/ /pubmed/33624723 http://dx.doi.org/10.1590/ACB360206 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Franco, Guilherme Galhardo Minto, Bruno Watanabe Dreibi, Rafael Manzini Costa, Jose Sergio Dias, Luis Gustavo Gosuen Gonçalves Percutaneous application of allogeneic adipose-derived mesenchymal stem cell in dogs submitted to minimally invasive plate osteosynthesis of the tibia |
title | Percutaneous application of allogeneic adipose-derived mesenchymal
stem cell in dogs submitted to minimally invasive plate osteosynthesis of the
tibia |
title_full | Percutaneous application of allogeneic adipose-derived mesenchymal
stem cell in dogs submitted to minimally invasive plate osteosynthesis of the
tibia |
title_fullStr | Percutaneous application of allogeneic adipose-derived mesenchymal
stem cell in dogs submitted to minimally invasive plate osteosynthesis of the
tibia |
title_full_unstemmed | Percutaneous application of allogeneic adipose-derived mesenchymal
stem cell in dogs submitted to minimally invasive plate osteosynthesis of the
tibia |
title_short | Percutaneous application of allogeneic adipose-derived mesenchymal
stem cell in dogs submitted to minimally invasive plate osteosynthesis of the
tibia |
title_sort | percutaneous application of allogeneic adipose-derived mesenchymal
stem cell in dogs submitted to minimally invasive plate osteosynthesis of the
tibia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902052/ https://www.ncbi.nlm.nih.gov/pubmed/33624723 http://dx.doi.org/10.1590/ACB360206 |
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