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Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment
Skeletal integrity is maintained through the tightly regulated bone remodeling process that occurs continuously throughout postnatal life to replace old bone and to repair skeletal damage. This is maintained primarily through complex interactions between bone resorbing osteoclasts and bone forming o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902060/ https://www.ncbi.nlm.nih.gov/pubmed/33634116 http://dx.doi.org/10.3389/fcell.2021.598612 |
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author | Arthur, Agnieszka Gronthos, Stan |
author_facet | Arthur, Agnieszka Gronthos, Stan |
author_sort | Arthur, Agnieszka |
collection | PubMed |
description | Skeletal integrity is maintained through the tightly regulated bone remodeling process that occurs continuously throughout postnatal life to replace old bone and to repair skeletal damage. This is maintained primarily through complex interactions between bone resorbing osteoclasts and bone forming osteoblasts. Other elements within the bone microenvironment, including stromal, osteogenic, hematopoietic, endothelial and neural cells, also contribute to maintaining skeletal integrity. Disruption of the dynamic interactions between these diverse cellular systems can lead to poor bone health and an increased susceptibility to skeletal diseases including osteopenia, osteoporosis, osteoarthritis, osteomalacia, and major fractures. Recent reports have implicated a direct role for the Eph tyrosine kinase receptors and their ephrin ligands during bone development, homeostasis and skeletal repair. These membrane-bound molecules mediate contact-dependent signaling through both the Eph receptors, termed forward signaling, and through the ephrin ligands, referred to as reverse signaling. This review will focus on Eph/ ephrin cross-talk as mediators of hematopoietic and stromal cell communication, and how these interactions contribute to blood/ bone marrow function and skeletal integrity during normal steady state or pathological conditions. |
format | Online Article Text |
id | pubmed-7902060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79020602021-02-24 Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment Arthur, Agnieszka Gronthos, Stan Front Cell Dev Biol Cell and Developmental Biology Skeletal integrity is maintained through the tightly regulated bone remodeling process that occurs continuously throughout postnatal life to replace old bone and to repair skeletal damage. This is maintained primarily through complex interactions between bone resorbing osteoclasts and bone forming osteoblasts. Other elements within the bone microenvironment, including stromal, osteogenic, hematopoietic, endothelial and neural cells, also contribute to maintaining skeletal integrity. Disruption of the dynamic interactions between these diverse cellular systems can lead to poor bone health and an increased susceptibility to skeletal diseases including osteopenia, osteoporosis, osteoarthritis, osteomalacia, and major fractures. Recent reports have implicated a direct role for the Eph tyrosine kinase receptors and their ephrin ligands during bone development, homeostasis and skeletal repair. These membrane-bound molecules mediate contact-dependent signaling through both the Eph receptors, termed forward signaling, and through the ephrin ligands, referred to as reverse signaling. This review will focus on Eph/ ephrin cross-talk as mediators of hematopoietic and stromal cell communication, and how these interactions contribute to blood/ bone marrow function and skeletal integrity during normal steady state or pathological conditions. Frontiers Media S.A. 2021-02-09 /pmc/articles/PMC7902060/ /pubmed/33634116 http://dx.doi.org/10.3389/fcell.2021.598612 Text en Copyright © 2021 Arthur and Gronthos. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Arthur, Agnieszka Gronthos, Stan Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment |
title | Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment |
title_full | Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment |
title_fullStr | Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment |
title_full_unstemmed | Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment |
title_short | Eph-Ephrin Signaling Mediates Cross-Talk Within the Bone Microenvironment |
title_sort | eph-ephrin signaling mediates cross-talk within the bone microenvironment |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902060/ https://www.ncbi.nlm.nih.gov/pubmed/33634116 http://dx.doi.org/10.3389/fcell.2021.598612 |
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