The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis

Objective  To analyze the expression of nuclear factor kappa B (NF-kB) and collagen type 1 on dental pulp after a treated combination of calcium hydroxide and propolis. Materials and Methods  The first maxillary molars of 30 rats were mechanically perforated. Teeth were divided into three groups of...

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Autores principales: Pribadi, Nirawati, Budiarti, Dwita, Kurniawan, Hendy Jaya, Widjiastuti, Ira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902100/
https://www.ncbi.nlm.nih.gov/pubmed/33412610
http://dx.doi.org/10.1055/s-0040-1716319
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author Pribadi, Nirawati
Budiarti, Dwita
Kurniawan, Hendy Jaya
Widjiastuti, Ira
author_facet Pribadi, Nirawati
Budiarti, Dwita
Kurniawan, Hendy Jaya
Widjiastuti, Ira
author_sort Pribadi, Nirawati
collection PubMed
description Objective  To analyze the expression of nuclear factor kappa B (NF-kB) and collagen type 1 on dental pulp after a treated combination of calcium hydroxide and propolis. Materials and Methods  The first maxillary molars of 30 rats were mechanically perforated. Teeth were divided into three groups of 10 for two separate extraction time frames, giving a total of 60 rats. The control groups were treated with Cention, the second treatment groups were treated with calcium hydroxide, and the third treatment groups were treated with a combination of calcium hydroxide and propolis. Final restoration was done with Cention. The teeth were extracted on days 7 and 14, and the expression of NF-kB and collagen type I was analyzed using immunohistochemistry. Results  There is lowest NF-kB expression and highest collagen type 1 expression on dental pulp after treated with a combination of calcium hydroxide and propolis on days 7 and 14 ( p < 0.05). Conclusion  The combination of calcium hydroxide and propolis inhibits pulp inflammation and stimulates regeneration through decreasing the NF-kB expression and increasing collagen type 1.
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spelling pubmed-79021002021-03-01 The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis Pribadi, Nirawati Budiarti, Dwita Kurniawan, Hendy Jaya Widjiastuti, Ira Eur J Dent Objective  To analyze the expression of nuclear factor kappa B (NF-kB) and collagen type 1 on dental pulp after a treated combination of calcium hydroxide and propolis. Materials and Methods  The first maxillary molars of 30 rats were mechanically perforated. Teeth were divided into three groups of 10 for two separate extraction time frames, giving a total of 60 rats. The control groups were treated with Cention, the second treatment groups were treated with calcium hydroxide, and the third treatment groups were treated with a combination of calcium hydroxide and propolis. Final restoration was done with Cention. The teeth were extracted on days 7 and 14, and the expression of NF-kB and collagen type I was analyzed using immunohistochemistry. Results  There is lowest NF-kB expression and highest collagen type 1 expression on dental pulp after treated with a combination of calcium hydroxide and propolis on days 7 and 14 ( p < 0.05). Conclusion  The combination of calcium hydroxide and propolis inhibits pulp inflammation and stimulates regeneration through decreasing the NF-kB expression and increasing collagen type 1. Thieme Medical and Scientific Publishers Pvt. Ltd. 2021-02 2021-01-07 /pmc/articles/PMC7902100/ /pubmed/33412610 http://dx.doi.org/10.1055/s-0040-1716319 Text en European Journal of Dentistry. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/). https://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Pribadi, Nirawati
Budiarti, Dwita
Kurniawan, Hendy Jaya
Widjiastuti, Ira
The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis
title The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis
title_full The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis
title_fullStr The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis
title_full_unstemmed The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis
title_short The NF-kB and Collagen Type 1 Expression in Dental Pulp after Treated Calcium Hydroxide Combined with Propolis
title_sort nf-kb and collagen type 1 expression in dental pulp after treated calcium hydroxide combined with propolis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902100/
https://www.ncbi.nlm.nih.gov/pubmed/33412610
http://dx.doi.org/10.1055/s-0040-1716319
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