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Constitutive Androstane Receptor-Mediated Inhibition of Metformin on Phase II Metabolic Enzyme SULT2A1

BACKGROUND: Metformin, as a first-line treatment for diabetes, interacts with many protein kinases and transcription factors which affect the expression of downstream target genes governing drug metabolism. Sulfotransferase, SULT2A1, one phase II metabolic enzyme, sulfonates both xenobiotic and endo...

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Detalles Bibliográficos
Autores principales:	Hu, Xiaowen, Li, Mengsiyu, Zhang, Chunxue, Pang, Shuguang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902148/ https://www.ncbi.nlm.nih.gov/pubmed/33643408 http://dx.doi.org/10.1155/2021/8867218

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