Cargando…
Neutrophil calprotectin identifies severe pulmonary disease in COVID-19
Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by respiratory failure. Although it has been suggested that elevated levels of blood neutrophils associate with worsening oxygenation in COVID-19, it is unknown whether neutrophils are drivers of the thrombo-inflammatory s...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902293/ https://www.ncbi.nlm.nih.gov/pubmed/32869342 http://dx.doi.org/10.1002/JLB.3COVCRA0720-359R |
_version_ | 1783654529487601664 |
---|---|
author | Shi, Hui Zuo, Yu Yalavarthi, Srilakshmi Gockman, Kelsey Zuo, Melanie Madison, Jacqueline A Blair, Christopher Woodward, Wrenn Lezak, Sean P Lugogo, Njira L Woods, Robert J Lood, Christian Knight, Jason S Kanthi, Yogendra |
author_facet | Shi, Hui Zuo, Yu Yalavarthi, Srilakshmi Gockman, Kelsey Zuo, Melanie Madison, Jacqueline A Blair, Christopher Woodward, Wrenn Lezak, Sean P Lugogo, Njira L Woods, Robert J Lood, Christian Knight, Jason S Kanthi, Yogendra |
author_sort | Shi, Hui |
collection | PubMed |
description | Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by respiratory failure. Although it has been suggested that elevated levels of blood neutrophils associate with worsening oxygenation in COVID-19, it is unknown whether neutrophils are drivers of the thrombo-inflammatory storm or simple bystanders. To better understand the potential role of neutrophils in COVID-19, we measured levels of the neutrophil activation marker S100A8/A9 (calprotectin) in hospitalized patients and determined its relationship to severity of illness and respiratory status. Patients with COVID-19 (n = 172) had markedly elevated levels of calprotectin in their blood. Calprotectin tracked with other acute phase reactants including C-reactive protein, ferritin, lactate dehydrogenase, and absolute neutrophil count, but was superior in identifying patients requiring mechanical ventilation. In longitudinal samples, calprotectin rose as oxygenation worsened. When tested on day 1 or 2 of hospitalization (n = 94 patients), calprotectin levels were significantly higher in patients who progressed to severe COVID-19 requiring mechanical ventilation (8039 ± 7031 ng/ml, n = 32) as compared to those who remained free of intubation (3365 ± 3146, P < 0.0001). In summary, serum calprotectin levels track closely with current and future COVID-19 severity, implicating neutrophils as potential perpetuators of inflammation and respiratory compromise in COVID-19. |
format | Online Article Text |
id | pubmed-7902293 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-79022932022-01-01 Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 Shi, Hui Zuo, Yu Yalavarthi, Srilakshmi Gockman, Kelsey Zuo, Melanie Madison, Jacqueline A Blair, Christopher Woodward, Wrenn Lezak, Sean P Lugogo, Njira L Woods, Robert J Lood, Christian Knight, Jason S Kanthi, Yogendra J Leukoc Biol Article Severe cases of coronavirus disease 2019 (COVID-19) are regularly complicated by respiratory failure. Although it has been suggested that elevated levels of blood neutrophils associate with worsening oxygenation in COVID-19, it is unknown whether neutrophils are drivers of the thrombo-inflammatory storm or simple bystanders. To better understand the potential role of neutrophils in COVID-19, we measured levels of the neutrophil activation marker S100A8/A9 (calprotectin) in hospitalized patients and determined its relationship to severity of illness and respiratory status. Patients with COVID-19 (n = 172) had markedly elevated levels of calprotectin in their blood. Calprotectin tracked with other acute phase reactants including C-reactive protein, ferritin, lactate dehydrogenase, and absolute neutrophil count, but was superior in identifying patients requiring mechanical ventilation. In longitudinal samples, calprotectin rose as oxygenation worsened. When tested on day 1 or 2 of hospitalization (n = 94 patients), calprotectin levels were significantly higher in patients who progressed to severe COVID-19 requiring mechanical ventilation (8039 ± 7031 ng/ml, n = 32) as compared to those who remained free of intubation (3365 ± 3146, P < 0.0001). In summary, serum calprotectin levels track closely with current and future COVID-19 severity, implicating neutrophils as potential perpetuators of inflammation and respiratory compromise in COVID-19. Oxford University Press 2020-09-01 /pmc/articles/PMC7902293/ /pubmed/32869342 http://dx.doi.org/10.1002/JLB.3COVCRA0720-359R Text en ©2020 Society for Leukocyte Biology https://academic.oup.com/pages/standard-publication-reuse-rightsThis article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights) This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections. |
spellingShingle | Article Shi, Hui Zuo, Yu Yalavarthi, Srilakshmi Gockman, Kelsey Zuo, Melanie Madison, Jacqueline A Blair, Christopher Woodward, Wrenn Lezak, Sean P Lugogo, Njira L Woods, Robert J Lood, Christian Knight, Jason S Kanthi, Yogendra Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 |
title | Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 |
title_full | Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 |
title_fullStr | Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 |
title_full_unstemmed | Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 |
title_short | Neutrophil calprotectin identifies severe pulmonary disease in COVID-19 |
title_sort | neutrophil calprotectin identifies severe pulmonary disease in covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902293/ https://www.ncbi.nlm.nih.gov/pubmed/32869342 http://dx.doi.org/10.1002/JLB.3COVCRA0720-359R |
work_keys_str_mv | AT shihui neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT zuoyu neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT yalavarthisrilakshmi neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT gockmankelsey neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT zuomelanie neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT madisonjacquelinea neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT blairchristopher neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT woodwardwrenn neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT lezakseanp neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT lugogonjiral neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT woodsrobertj neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT loodchristian neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT knightjasons neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 AT kanthiyogendra neutrophilcalprotectinidentifiesseverepulmonarydiseaseincovid19 |