Oral berberine improves brain dopa/dopamine levels to ameliorate Parkinson’s disease by regulating gut microbiota

The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is the rate-limiting enzyme that hydroxylates tyrosine and generates levodopa (l-dopa) with tetrahydrobiopterin (BH(4)) as a coenzyme. Here, we show that oral berberine (BBR) m...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Tong, Qian, Ma, Shu-Rong, Zhao, Zhen-Xiong, Pan, Li-Bin, Cong, Lin, Han, Pei, Peng, Ran, Yu, Hang, Lin, Yuan, Gao, Tian-Le, Shou, Jia-Wen, Li, Xiao-Yang, Zhang, Xian-Feng, Zhang, Zheng-Wei, Fu, Jie, Wen, Bao-Ying, Yu, Jin-Bo, Cao, Xuetao, Jiang, Jian-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902645/
https://www.ncbi.nlm.nih.gov/pubmed/33623004
http://dx.doi.org/10.1038/s41392-020-00456-5

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