Cargando…

Screening of metabolic modulators identifies new strategies to target metabolic reprogramming in melanoma

The prognosis of metastatic melanoma remains poor due to de novo or acquired resistance to immune and targeted therapies. Previous studies have shown that melanoma cells have perturbed metabolism and that cellular metabolic pathways represent potential therapeutic targets. To support the discovery o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Abildgaard, Cecilie, Rizza, Salvatore, Christiansen, Helle, Schmidt, Steffen, Dahl, Christina, Abdul-Al, Ahmad, Christensen, Annette, Filomeni, Giuseppe, Guldberg, Per
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902673/ https://www.ncbi.nlm.nih.gov/pubmed/33623106 http://dx.doi.org/10.1038/s41598-021-83796-8

Ejemplares similares

Inhibition of retinoic acid receptor β signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells
por: Abildgaard, Cecilie, et al.
Publicado: (2017)

Bioenergetic modulation with dichloroacetate reduces the growth of melanoma cells and potentiates their response to BRAF(V600E) inhibition
por: Abildgaard, Cecilie, et al.
Publicado: (2014)

Editorial: Redox and Metabolic Circuits in Cancer
por: Rizza, Salvatore, et al.
Publicado: (2018)

TRAP1: A Metabolic Hub Linking Aging Pathophysiology to Mitochondrial S-Nitrosylation
por: Faienza, Fiorella, et al.
Publicado: (2020)

Role, Targets and Regulation of (de)nitrosylation in Malignancy
por: Rizza, Salvatore, et al.
Publicado: (2018)

Dysfunctional oxidative phosphorylation makes malignant melanoma cells addicted to glycolysis driven by the (V600E)BRAF oncogene
por: Hall, Arnaldur, et al.
Publicado: (2013)

Use of Computational Biochemistry for Elucidating Molecular Mechanisms of Nitric Oxide Synthase
por: Bignon, Emmanuelle, et al.
Publicado: (2019)

Established Principles and Emerging Concepts on the Interplay between Mitochondrial Physiology and S-(De)nitrosylation: Implications in Cancer and Neurodegeneration
por: Di Giacomo, Giuseppina, et al.
Publicado: (2012)

S-Nitrosation and Ubiquitin-Proteasome System Interplay in Neuromuscular Disorders
por: Rizza, Salvatore, et al.
Publicado: (2014)

Lipid metabolic Reprogramming: Role in Melanoma Progression and Therapeutic Perspectives
por: Pellerin, Laurence, et al.
Publicado: (2020)

Lactate Rewrites the Metabolic Reprogramming of Uveal Melanoma Cells and Induces Quiescence Phenotype
por: Longhitano, Lucia, et al.
Publicado: (2022)

A ligation assay for multiplex analysis of CpG methylation using bisulfite-treated DNA
por: Dahl, Christina, et al.
Publicado: (2007)

Loss of Ambra1 promotes melanoma growth and invasion
por: Di Leo, Luca, et al.
Publicado: (2021)

Nitric oxide-based regulation of metabolism: Hints from TRAP1 and SIRT3 crosstalk
por: Faienza, Fiorella, et al.
Publicado: (2022)

Metabolic reprogramming in prostate cancer
por: Ahmad, Fahim, et al.
Publicado: (2021)

Metabolic Reprogramming in Metastatic Melanoma with Acquired Resistance to Targeted Therapies: Integrative Metabolomic and Proteomic Analysis
por: Soumoy, Laura, et al.
Publicado: (2020)

The ERK and JNK pathways in the regulation of metabolic reprogramming
por: Papa, Salvatore, et al.
Publicado: (2018)

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma
por: Gu, Zhichao, et al.
Publicado: (2017)

The Impact of Olive Oil Compounds on the Metabolic Reprogramming of Cutaneous Melanoma Cell Models
por: Brito, Cheila, et al.
Publicado: (2021)

Immune cell metabolism and metabolic reprogramming
por: Hu, Chenchen, et al.
Publicado: (2022)

Editorial: Metabolic reprogramming in breast cancer
por: Scatena, Cristian, et al.
Publicado: (2022)

Metabolic Reprogramming in Glioma
por: Strickland, Marie, et al.
Publicado: (2017)

Metabolic reprogramming of metastatic breast cancer and melanoma by let-7a microRNA
por: Serguienko, Anastassia, et al.
Publicado: (2014)

Thymidine Kinase 1 Drives Skin Cutaneous Melanoma Malignant Progression and Metabolic Reprogramming
por: Zuo, Sipeng, et al.
Publicado: (2022)

Oxidative stress and autophagy: the clash between damage and metabolic needs
por: Filomeni, G, et al.
Publicado: (2015)

Mitochondrial Metabolism in Melanoma
por: Huang, Christina, et al.
Publicado: (2021)

Redox proteome analysis of auranofin exposed ovarian cancer cells (A2780)
por: Chiappetta, Giovanni, et al.
Publicado: (2022)

Metabolic Reprograming in Macrophage Polarization
por: Galván-Peña, Silvia, et al.
Publicado: (2014)

Metabolic Reprogramming in Thyroid Carcinoma
por: Coelho, Raquel Guimaraes, et al.
Publicado: (2018)

Metabolic Reprogramming in Health and Disease
por: Chiellini, Grazia
Publicado: (2020)

Metabolic Reprogramming and Vulnerabilities in Cancer
por: Lyssiotis, Costas A., et al.
Publicado: (2019)

Metabolic reprogramming in macrophage responses
por: Liu, Yang, et al.
Publicado: (2021)

Metabolic Reprogramming in COVID-19
por: Shen, Tao, et al.
Publicado: (2021)

Metabolic Reprogramming and Renal Fibrosis
por: Zhu, Xiaoyu, et al.
Publicado: (2021)

Metabolic Reprogramming of Liver Fibrosis
por: Delgado, M. Eugenia, et al.
Publicado: (2021)

MYCN and Metabolic Reprogramming in Neuroblastoma
por: Bansal, Mohit, et al.
Publicado: (2022)

Metabolic reprogramming of pulmonary fibrosis
por: Li, Jiaxin, et al.
Publicado: (2022)

Emerging Hallmarks of Metabolic Reprogramming in Prostate Cancer
por: Lasorsa, Francesco, et al.
Publicado: (2023)

Metabolic reprogramming of the ovarian cancer microenvironment in the development of antiangiogenic resistance: Metabolic reprogramming of the OC microenvironment
por: Yue, Huiran, et al.
Publicado: (2023)

Metabolic Reprogramming of HCC: A New Microenvironment for Immune Responses
por: Foglia, Beatrice, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_vg2f5fdpbomuc55smvbu6ndh0n