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Noisy Synaptic Conductance: Bug or a Feature?
More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information tr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Applied Science Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902755/ https://www.ncbi.nlm.nih.gov/pubmed/32459990 http://dx.doi.org/10.1016/j.tins.2020.03.009 |
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author | Rusakov, Dmitri A. Savtchenko, Leonid P. Latham, Peter E. |
author_facet | Rusakov, Dmitri A. Savtchenko, Leonid P. Latham, Peter E. |
author_sort | Rusakov, Dmitri A. |
collection | PubMed |
description | More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across synapses, this seems both wasteful and inefficient. However, synaptic noise arising from variable transmission can improve, in certain restricted conditions, information transmission. Under broader conditions, it can improve information transmission per release, a quantity that is relevant given the energetic constraints on computing in the brain. Here we discuss the role, both positive and negative, synaptic noise plays in information transmission and computation in the brain. |
format | Online Article Text |
id | pubmed-7902755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier Applied Science Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-79027552021-03-03 Noisy Synaptic Conductance: Bug or a Feature? Rusakov, Dmitri A. Savtchenko, Leonid P. Latham, Peter E. Trends Neurosci Opinion More often than not, action potentials fail to trigger neurotransmitter release. And even when neurotransmitter is released, the resulting change in synaptic conductance is highly variable. Given the energetic cost of generating and propagating action potentials, and the importance of information transmission across synapses, this seems both wasteful and inefficient. However, synaptic noise arising from variable transmission can improve, in certain restricted conditions, information transmission. Under broader conditions, it can improve information transmission per release, a quantity that is relevant given the energetic constraints on computing in the brain. Here we discuss the role, both positive and negative, synaptic noise plays in information transmission and computation in the brain. Elsevier Applied Science Publishing 2020-06 /pmc/articles/PMC7902755/ /pubmed/32459990 http://dx.doi.org/10.1016/j.tins.2020.03.009 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Opinion Rusakov, Dmitri A. Savtchenko, Leonid P. Latham, Peter E. Noisy Synaptic Conductance: Bug or a Feature? |
title | Noisy Synaptic Conductance: Bug or a Feature? |
title_full | Noisy Synaptic Conductance: Bug or a Feature? |
title_fullStr | Noisy Synaptic Conductance: Bug or a Feature? |
title_full_unstemmed | Noisy Synaptic Conductance: Bug or a Feature? |
title_short | Noisy Synaptic Conductance: Bug or a Feature? |
title_sort | noisy synaptic conductance: bug or a feature? |
topic | Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902755/ https://www.ncbi.nlm.nih.gov/pubmed/32459990 http://dx.doi.org/10.1016/j.tins.2020.03.009 |
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