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CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction
Automatic extraction of chemical-induced disease (CID) relation from unstructured text is of essential importance for disease treatment and drug development. In this task, some relational facts can only be inferred from the document rather than single sentence. Recently, researchers investigate grap...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902761/ https://www.ncbi.nlm.nih.gov/pubmed/33643385 http://dx.doi.org/10.3389/fgene.2021.624307 |
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author | Zeng, Daojian Zhao, Chao Quan, Zhe |
author_facet | Zeng, Daojian Zhao, Chao Quan, Zhe |
author_sort | Zeng, Daojian |
collection | PubMed |
description | Automatic extraction of chemical-induced disease (CID) relation from unstructured text is of essential importance for disease treatment and drug development. In this task, some relational facts can only be inferred from the document rather than single sentence. Recently, researchers investigate graph-based approaches to extract relations across sentences. It iteratively combines the information from neighbor nodes to model the interactions in entity mentions that exist in different sentences. Despite their success, one severe limitation of the graph-based approaches is the over-smoothing problem, which decreases the model distinguishing ability. In this paper, we propose CID-GCN, an effective Graph Convolutional Networks (GCNs) with gating mechanism, for CID relation extraction. Specifically, we construct a heterogeneous graph which contains mention, sentence and entity nodes. Then, the graph convolution operation is employed to aggregate interactive information on the constructed graph. Particularly, we combine gating mechanism with the graph convolution operation to address the over-smoothing problem. The experimental results demonstrate that our approach significantly outperforms the baselines. |
format | Online Article Text |
id | pubmed-7902761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79027612021-02-25 CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction Zeng, Daojian Zhao, Chao Quan, Zhe Front Genet Genetics Automatic extraction of chemical-induced disease (CID) relation from unstructured text is of essential importance for disease treatment and drug development. In this task, some relational facts can only be inferred from the document rather than single sentence. Recently, researchers investigate graph-based approaches to extract relations across sentences. It iteratively combines the information from neighbor nodes to model the interactions in entity mentions that exist in different sentences. Despite their success, one severe limitation of the graph-based approaches is the over-smoothing problem, which decreases the model distinguishing ability. In this paper, we propose CID-GCN, an effective Graph Convolutional Networks (GCNs) with gating mechanism, for CID relation extraction. Specifically, we construct a heterogeneous graph which contains mention, sentence and entity nodes. Then, the graph convolution operation is employed to aggregate interactive information on the constructed graph. Particularly, we combine gating mechanism with the graph convolution operation to address the over-smoothing problem. The experimental results demonstrate that our approach significantly outperforms the baselines. Frontiers Media S.A. 2021-02-10 /pmc/articles/PMC7902761/ /pubmed/33643385 http://dx.doi.org/10.3389/fgene.2021.624307 Text en Copyright © 2021 Zeng, Zhao and Quan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Zeng, Daojian Zhao, Chao Quan, Zhe CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction |
title | CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction |
title_full | CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction |
title_fullStr | CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction |
title_full_unstemmed | CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction |
title_short | CID-GCN: An Effective Graph Convolutional Networks for Chemical-Induced Disease Relation Extraction |
title_sort | cid-gcn: an effective graph convolutional networks for chemical-induced disease relation extraction |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902761/ https://www.ncbi.nlm.nih.gov/pubmed/33643385 http://dx.doi.org/10.3389/fgene.2021.624307 |
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