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Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication

Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether...

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Autores principales: Fink, Asbjørn, Knudsen, Andreas Dehlbæk, Thudium, Rebekka Faber, Von Stemann, Jakob Hjorth, Afzal, Shoaib, Lundgren, Jens, Kirkegaard-Klitbo, Ditte Marie, Ostrowski, Sisse Rye, Nordestgaard, Børge G., Nielsen, Susanne Dam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902813/
https://www.ncbi.nlm.nih.gov/pubmed/33623050
http://dx.doi.org/10.1038/s41598-021-83731-x
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author Fink, Asbjørn
Knudsen, Andreas Dehlbæk
Thudium, Rebekka Faber
Von Stemann, Jakob Hjorth
Afzal, Shoaib
Lundgren, Jens
Kirkegaard-Klitbo, Ditte Marie
Ostrowski, Sisse Rye
Nordestgaard, Børge G.
Nielsen, Susanne Dam
author_facet Fink, Asbjørn
Knudsen, Andreas Dehlbæk
Thudium, Rebekka Faber
Von Stemann, Jakob Hjorth
Afzal, Shoaib
Lundgren, Jens
Kirkegaard-Klitbo, Ditte Marie
Ostrowski, Sisse Rye
Nordestgaard, Børge G.
Nielsen, Susanne Dam
author_sort Fink, Asbjørn
collection PubMed
description Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II–VII–X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7–2.9), P < 0.001) and low coagulation factor II–VII–X (aOR 1.4 (95% CI 1.0–1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II–VII–X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II–VII–X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection.
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spelling pubmed-79028132021-02-25 Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication Fink, Asbjørn Knudsen, Andreas Dehlbæk Thudium, Rebekka Faber Von Stemann, Jakob Hjorth Afzal, Shoaib Lundgren, Jens Kirkegaard-Klitbo, Ditte Marie Ostrowski, Sisse Rye Nordestgaard, Børge G. Nielsen, Susanne Dam Sci Rep Article Altered coagulation has been reported in people living with HIV (PLWH) with ongoing viral replication and may predispose to cardiovascular diseases. However, less is known about coagulation in PLWH with undetectable viral replication. In a cross-sectional observational study, we investigated whether HIV infection with undetectable viral replication is independently associated with activated partial thromboplastin time (APTT) and coagulation factor II–VII–X concentrations out of reference. Logistic regression analyses were used to assess the association of HIV infection with APTT and coagulation factor II–VII–X, after adjusting for age, sex, smoking status, alcohol consumption, BMI, diabetes and hsCRP. 936 PLWH with undetectable viral replication from the Copenhagen Co-morbidity in HIV infection study (COCOMO-study) and 2955 uninfected controls were included. Higher prevalence of short APTT was found in PLWH compared to controls (13.5% vs. 7.6%, P < 0.001). Furthermore, higher prevalence of low coagulation factor II–VII–X was found in PLWH than in controls (9.6% vs. 7.4%, P = 0.022). HIV was independently associated with short APTT (adjusted odds ratio (aOR) 2.3 (95% CI 1.7–2.9), P < 0.001) and low coagulation factor II–VII–X (aOR 1.4 (95% CI 1.0–1.9), P = 0.046). Few participants among PLWH and controls had both short APTT and low coagulation factor II–VII–X, 2.1% vs. 0.8%, respectively. We found evidence of both procoagulant (short APTT) and anticoagulant (low coagulation factor II–VII–X) alterations in PLWH with undetectable viral replication, and our findings suggest that two different coagulation phenotypes exist in participants with treated HIV infection. Nature Publishing Group UK 2021-02-23 /pmc/articles/PMC7902813/ /pubmed/33623050 http://dx.doi.org/10.1038/s41598-021-83731-x Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fink, Asbjørn
Knudsen, Andreas Dehlbæk
Thudium, Rebekka Faber
Von Stemann, Jakob Hjorth
Afzal, Shoaib
Lundgren, Jens
Kirkegaard-Klitbo, Ditte Marie
Ostrowski, Sisse Rye
Nordestgaard, Børge G.
Nielsen, Susanne Dam
Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_full Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_fullStr Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_full_unstemmed Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_short Identification of two different coagulation phenotypes in people living with HIV with undetectable viral replication
title_sort identification of two different coagulation phenotypes in people living with hiv with undetectable viral replication
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902813/
https://www.ncbi.nlm.nih.gov/pubmed/33623050
http://dx.doi.org/10.1038/s41598-021-83731-x
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