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Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency
The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is an intermediate and reversible state that often precedes dependency and therefore, its identification may be essential to...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902838/ https://www.ncbi.nlm.nih.gov/pubmed/33623057 http://dx.doi.org/10.1038/s41598-021-83991-7 |
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author | Alberro, Ainhoa Iribarren-Lopez, Andrea Sáenz-Cuesta, Matías Matheu, Ander Vergara, Itziar Otaegui, David |
author_facet | Alberro, Ainhoa Iribarren-Lopez, Andrea Sáenz-Cuesta, Matías Matheu, Ander Vergara, Itziar Otaegui, David |
author_sort | Alberro, Ainhoa |
collection | PubMed |
description | The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is an intermediate and reversible state that often precedes dependency and therefore, its identification may be essential to prevent dependency. However, there is no consensus on the best tools to identify frailty. In this sense, diverse molecules have been proposed as potential biomarkers. Some investigations pointed to an increased chronic inflammation or inflammaging with frailty, while others did not report such differences. In this work, we evaluated the circulating concentration of the inflammaging markers in adults and older adults (aged over 70 years) by ELISA and Luminex techniques. The Barthel Index was applied for the evaluation of dependency and Timed up-and-go, Gait Speed, Short Physical Performance Battery, Tilburg Frailty Indicator and Gerontopole Frailty Screening Tool were used for the identification of frailty. CRP, TNF-α, IL-6 and albumin concentrations were measured, and we found that elevated inflammation is present in older adults, while no differences with frailty and dependency were reported. Our results were consistent for all the evaluated frailty scales, highlighting the need to reconsider increased inflammation as a biomarker of frailty. |
format | Online Article Text |
id | pubmed-7902838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79028382021-02-25 Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency Alberro, Ainhoa Iribarren-Lopez, Andrea Sáenz-Cuesta, Matías Matheu, Ander Vergara, Itziar Otaegui, David Sci Rep Article The improvement of life quality and medical advances has resulted in increased life expectancy. Despite this, health status commonly worsens in the last years of life. Frailty is an intermediate and reversible state that often precedes dependency and therefore, its identification may be essential to prevent dependency. However, there is no consensus on the best tools to identify frailty. In this sense, diverse molecules have been proposed as potential biomarkers. Some investigations pointed to an increased chronic inflammation or inflammaging with frailty, while others did not report such differences. In this work, we evaluated the circulating concentration of the inflammaging markers in adults and older adults (aged over 70 years) by ELISA and Luminex techniques. The Barthel Index was applied for the evaluation of dependency and Timed up-and-go, Gait Speed, Short Physical Performance Battery, Tilburg Frailty Indicator and Gerontopole Frailty Screening Tool were used for the identification of frailty. CRP, TNF-α, IL-6 and albumin concentrations were measured, and we found that elevated inflammation is present in older adults, while no differences with frailty and dependency were reported. Our results were consistent for all the evaluated frailty scales, highlighting the need to reconsider increased inflammation as a biomarker of frailty. Nature Publishing Group UK 2021-02-23 /pmc/articles/PMC7902838/ /pubmed/33623057 http://dx.doi.org/10.1038/s41598-021-83991-7 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Alberro, Ainhoa Iribarren-Lopez, Andrea Sáenz-Cuesta, Matías Matheu, Ander Vergara, Itziar Otaegui, David Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
title | Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
title_full | Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
title_fullStr | Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
title_full_unstemmed | Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
title_short | Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
title_sort | inflammaging markers characteristic of advanced age show similar levels with frailty and dependency |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902838/ https://www.ncbi.nlm.nih.gov/pubmed/33623057 http://dx.doi.org/10.1038/s41598-021-83991-7 |
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