De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ

Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association be...

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Detalles Bibliográficos
Autores principales: Nabrinsky, Edward, Masood, Faisal, AbdulMujeeb, Sufyan, Asado, Nahren, Almanaseer, Imad, Galvez, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902915/
https://www.ncbi.nlm.nih.gov/pubmed/33665080
http://dx.doi.org/10.1016/j.lrr.2021.100237
Descripción
Sumario:Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association between BRCA carriers and AML. We report a case of a young female BRCA carrier who develops de novo AML without prior chemoradiation treatment, and examine if there is a link between BRCA and developing leukemia.

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