De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ

Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association be...

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Autores principales: Nabrinsky, Edward, Masood, Faisal, AbdulMujeeb, Sufyan, Asado, Nahren, Almanaseer, Imad, Galvez, Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902915/
https://www.ncbi.nlm.nih.gov/pubmed/33665080
http://dx.doi.org/10.1016/j.lrr.2021.100237
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author Nabrinsky, Edward
Masood, Faisal
AbdulMujeeb, Sufyan
Asado, Nahren
Almanaseer, Imad
Galvez, Angel
author_facet Nabrinsky, Edward
Masood, Faisal
AbdulMujeeb, Sufyan
Asado, Nahren
Almanaseer, Imad
Galvez, Angel
author_sort Nabrinsky, Edward
collection PubMed
description Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association between BRCA carriers and AML. We report a case of a young female BRCA carrier who develops de novo AML without prior chemoradiation treatment, and examine if there is a link between BRCA and developing leukemia.
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spelling pubmed-79029152021-03-03 De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ Nabrinsky, Edward Masood, Faisal AbdulMujeeb, Sufyan Asado, Nahren Almanaseer, Imad Galvez, Angel Leuk Res Rep Article Acute myeloid leukemia (AML) is primarily a disease of older adults and can arise de novo, in relation to previous treatment or in the setting of underlying hematological disease. While it is known to arise from chemoradiation in the setting of breast cancer, little is known about the association between BRCA carriers and AML. We report a case of a young female BRCA carrier who develops de novo AML without prior chemoradiation treatment, and examine if there is a link between BRCA and developing leukemia. Elsevier 2021-02-09 /pmc/articles/PMC7902915/ /pubmed/33665080 http://dx.doi.org/10.1016/j.lrr.2021.100237 Text en © 2021 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Nabrinsky, Edward
Masood, Faisal
AbdulMujeeb, Sufyan
Asado, Nahren
Almanaseer, Imad
Galvez, Angel
De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ
title De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ
title_full De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ
title_fullStr De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ
title_full_unstemmed De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ
title_short De-novo acute myeloid leukemia in a BRCA positive female with locally treated ductal carcinoma In Situ
title_sort de-novo acute myeloid leukemia in a brca positive female with locally treated ductal carcinoma in situ
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902915/
https://www.ncbi.nlm.nih.gov/pubmed/33665080
http://dx.doi.org/10.1016/j.lrr.2021.100237
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