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Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer’s Disease, Without Altering Amyloid-β and Tau Pathologies

BACKGROUND: Alzheimer’s disease (AD) is a multifactorial disease, implying that multi-target treatments may be necessary to effectively cure AD. Tetrahydrobiopterin (BH4) is an enzymatic cofactor required for the synthesis of monoamines and nitric oxide that also exerts antioxidant and anti-inflamma...

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Detalles Bibliográficos
Autores principales:	Fanet, Hortense, Tournissac, Marine, Leclerc, Manon, Caron, Vicky, Tremblay, Cyntia, Vancassel, Sylvie, Calon, Frédéric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902975/ https://www.ncbi.nlm.nih.gov/pubmed/33337360 http://dx.doi.org/10.3233/JAD-200637

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