Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis

Sarcoidosis is a multisystem inflammatory disorder of uncertain aetiology. There are numerous case reports of sarcoidosis occurring during treatment with biological immunotherapies. Here, we describe the case of a 52-year-old woman with psoriatic arthritis who developed multisystem sarcoidosis while...

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Detalles Bibliográficos
Autores principales: Kirby, Colm, Herlihy, Darragh, Clarke, Lindsey, Mullan, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903082/
https://www.ncbi.nlm.nih.gov/pubmed/33619146
http://dx.doi.org/10.1136/bcr-2020-240615
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author Kirby, Colm
Herlihy, Darragh
Clarke, Lindsey
Mullan, Ronan
author_facet Kirby, Colm
Herlihy, Darragh
Clarke, Lindsey
Mullan, Ronan
author_sort Kirby, Colm
collection PubMed
description Sarcoidosis is a multisystem inflammatory disorder of uncertain aetiology. There are numerous case reports of sarcoidosis occurring during treatment with biological immunotherapies. Here, we describe the case of a 52-year-old woman with psoriatic arthritis who developed multisystem sarcoidosis while being treated with secukinumab (anti-interleukin-17A) therapy which, to our knowledge, is the first such case. We discuss existing literature and hypothesise that IL-17 blockade may precipitate the development of granulomatous disease.
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spelling pubmed-79030822021-03-09 Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis Kirby, Colm Herlihy, Darragh Clarke, Lindsey Mullan, Ronan BMJ Case Rep Case Report Sarcoidosis is a multisystem inflammatory disorder of uncertain aetiology. There are numerous case reports of sarcoidosis occurring during treatment with biological immunotherapies. Here, we describe the case of a 52-year-old woman with psoriatic arthritis who developed multisystem sarcoidosis while being treated with secukinumab (anti-interleukin-17A) therapy which, to our knowledge, is the first such case. We discuss existing literature and hypothesise that IL-17 blockade may precipitate the development of granulomatous disease. BMJ Publishing Group 2021-02-22 /pmc/articles/PMC7903082/ /pubmed/33619146 http://dx.doi.org/10.1136/bcr-2020-240615 Text en © BMJ Publishing Group Limited 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Case Report
Kirby, Colm
Herlihy, Darragh
Clarke, Lindsey
Mullan, Ronan
Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
title Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
title_full Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
title_fullStr Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
title_full_unstemmed Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
title_short Sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
title_sort sarcoidosis manifesting during treatment with secukinumab for psoriatic arthritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903082/
https://www.ncbi.nlm.nih.gov/pubmed/33619146
http://dx.doi.org/10.1136/bcr-2020-240615
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AT clarkelindsey sarcoidosismanifestingduringtreatmentwithsecukinumabforpsoriaticarthritis
AT mullanronan sarcoidosismanifestingduringtreatmentwithsecukinumabforpsoriaticarthritis

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