The A150V Polymorphism of Genotype 3 Hepatitis C Virus Polymerase Inhibits Interferon Alfa by Suppressing Protein Kinase R Activation

BACKGROUND & AIMS: Despite recent advances in antiviral therapy for hepatitis C virus (HCV), a proportion of patients with genotype 3 (G3) HCV infection do not respond to current all oral treatment regimens. Genomic analyses have identified key polymorphisms correlating with increased resistance...

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Detalles Bibliográficos
Autores principales: Lee, Wing-Yiu Jason, Jones, Meleri, Wing, Peter A.C., Rajagopal, Swathi, Foster, Graham R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903130/
https://www.ncbi.nlm.nih.gov/pubmed/33248325
http://dx.doi.org/10.1016/j.jcmgh.2020.11.012

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