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Tea eggs-inspired high-strength natural polymer hydrogels

Natural polymer (NP) hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety; however, the intrinsic poor mechanical strengths severely limit their applications as structural tissue engineering scaffolds. Inspired by the stiffening albumen gel of tea eggs, a traditio...

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Autores principales: Wu, Tengling, Cui, Chunyan, Fan, Chuanchuan, Xu, Ziyang, Liu, Yang, Liu, Wenguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903155/
https://www.ncbi.nlm.nih.gov/pubmed/33718664
http://dx.doi.org/10.1016/j.bioactmat.2021.02.009
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author Wu, Tengling
Cui, Chunyan
Fan, Chuanchuan
Xu, Ziyang
Liu, Yang
Liu, Wenguang
author_facet Wu, Tengling
Cui, Chunyan
Fan, Chuanchuan
Xu, Ziyang
Liu, Yang
Liu, Wenguang
author_sort Wu, Tengling
collection PubMed
description Natural polymer (NP) hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety; however, the intrinsic poor mechanical strengths severely limit their applications as structural tissue engineering scaffolds. Inspired by the stiffening albumen gel of tea eggs, a traditional Chinese snack, high-strength NP hydrogels are constructed by simply soaking in aqueous solution of tea polyphenols (TP), an active ingredient extracted from tea. The TP-treated representative NP hydrogels exhibit considerably enhanced multifaceted mechanical properties with maximum 19-/30-, 8.4-, 6.1-, 72-fold increases in tensile/compressive strengths, Young's modulus, elongation at break and facture toughness, respectively, compared with pristine hydrogels, primarily due to the hydrogen bonding interactions between TP and NP chains. The TP-treated NP hydrogels can resist different large deformations, which cannot be achieved by their original species at all. In aqueous solution, the TP-treated NP hydrogels can still maintain robust mechanical performances, in spite of somewhat decline in strengths with release of TP, which just favorably affords increased water contents, antibacterial and antioxidant activities. GelMA-TP hydrogel is shown to facilitate wound healing in a full-thickness skin defect model. Importantly, the weak 3D printed GelMA scaffolds are significantly strengthened by TP treatment, broadening the possibility for customizing individualized bioscaffolds.
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spelling pubmed-79031552021-03-12 Tea eggs-inspired high-strength natural polymer hydrogels Wu, Tengling Cui, Chunyan Fan, Chuanchuan Xu, Ziyang Liu, Yang Liu, Wenguang Bioact Mater Article Natural polymer (NP) hydrogels are an irreplaceable class of biomaterials owing to their identified biosafety; however, the intrinsic poor mechanical strengths severely limit their applications as structural tissue engineering scaffolds. Inspired by the stiffening albumen gel of tea eggs, a traditional Chinese snack, high-strength NP hydrogels are constructed by simply soaking in aqueous solution of tea polyphenols (TP), an active ingredient extracted from tea. The TP-treated representative NP hydrogels exhibit considerably enhanced multifaceted mechanical properties with maximum 19-/30-, 8.4-, 6.1-, 72-fold increases in tensile/compressive strengths, Young's modulus, elongation at break and facture toughness, respectively, compared with pristine hydrogels, primarily due to the hydrogen bonding interactions between TP and NP chains. The TP-treated NP hydrogels can resist different large deformations, which cannot be achieved by their original species at all. In aqueous solution, the TP-treated NP hydrogels can still maintain robust mechanical performances, in spite of somewhat decline in strengths with release of TP, which just favorably affords increased water contents, antibacterial and antioxidant activities. GelMA-TP hydrogel is shown to facilitate wound healing in a full-thickness skin defect model. Importantly, the weak 3D printed GelMA scaffolds are significantly strengthened by TP treatment, broadening the possibility for customizing individualized bioscaffolds. KeAi Publishing 2021-02-18 /pmc/articles/PMC7903155/ /pubmed/33718664 http://dx.doi.org/10.1016/j.bioactmat.2021.02.009 Text en © 2021 [The Author/The Authors] http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Wu, Tengling
Cui, Chunyan
Fan, Chuanchuan
Xu, Ziyang
Liu, Yang
Liu, Wenguang
Tea eggs-inspired high-strength natural polymer hydrogels
title Tea eggs-inspired high-strength natural polymer hydrogels
title_full Tea eggs-inspired high-strength natural polymer hydrogels
title_fullStr Tea eggs-inspired high-strength natural polymer hydrogels
title_full_unstemmed Tea eggs-inspired high-strength natural polymer hydrogels
title_short Tea eggs-inspired high-strength natural polymer hydrogels
title_sort tea eggs-inspired high-strength natural polymer hydrogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903155/
https://www.ncbi.nlm.nih.gov/pubmed/33718664
http://dx.doi.org/10.1016/j.bioactmat.2021.02.009
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