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Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy

OBJECTIVES: The vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE)...

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Autores principales: Dordevic, Milos, Gruber, Julia, Schmitt, Friedhelm C, Mueller, Notger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903167/
https://www.ncbi.nlm.nih.gov/pubmed/33681800
http://dx.doi.org/10.1136/bmjno-2020-000077
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author Dordevic, Milos
Gruber, Julia
Schmitt, Friedhelm C
Mueller, Notger
author_facet Dordevic, Milos
Gruber, Julia
Schmitt, Friedhelm C
Mueller, Notger
author_sort Dordevic, Milos
collection PubMed
description OBJECTIVES: The vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE) with their functional and possible structural temporal lobe pathology should show deficits in vestibular-related behaviour. This study aimed at assessing behavioural deficits related to a suspected disturbance of the vestibulo-MTL axis in patients with TLE. METHODS: Twenty patients with TLE (46.7±15.1 years, seven females) and their age-matched and gender-matched controls (46.7±15.1, seven females) underwent three test batteries that challenged vestibular and MTL functions: balancing, path integration (triangle completion test) and rotational memory. In addition, participants underwent a structural MRI for grey matter analysis using voxel-based morphometry. RESULTS: Compared with controls, patients with TLE showed significantly inferior performance in all three behavioural tests, with large effect sizes. There were no significant grey matter differences between the two groups. CONCLUSION: These results indicate a potential disturbance in the vestibulo-MTL axis in TLE; these are to be verified by future large-scale studies. In the current study, these behavioural deficits emerged without evidence of any brain volume differences between the patients and their controls as depicted by high-resolution MRI. This speaks for a dissociation between functional and structural alterations in TLE.
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spelling pubmed-79031672021-03-04 Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy Dordevic, Milos Gruber, Julia Schmitt, Friedhelm C Mueller, Notger BMJ Neurol Open Original Research OBJECTIVES: The vestibulo-medial temporal lobe (MTL) axis model proposes that the vestibular system and the MTL are tightly linked both structurally and functionally so that alterations of one structure should entail disturbances in the other. Accordingly, patients with temporal lobe epilepsy (TLE) with their functional and possible structural temporal lobe pathology should show deficits in vestibular-related behaviour. This study aimed at assessing behavioural deficits related to a suspected disturbance of the vestibulo-MTL axis in patients with TLE. METHODS: Twenty patients with TLE (46.7±15.1 years, seven females) and their age-matched and gender-matched controls (46.7±15.1, seven females) underwent three test batteries that challenged vestibular and MTL functions: balancing, path integration (triangle completion test) and rotational memory. In addition, participants underwent a structural MRI for grey matter analysis using voxel-based morphometry. RESULTS: Compared with controls, patients with TLE showed significantly inferior performance in all three behavioural tests, with large effect sizes. There were no significant grey matter differences between the two groups. CONCLUSION: These results indicate a potential disturbance in the vestibulo-MTL axis in TLE; these are to be verified by future large-scale studies. In the current study, these behavioural deficits emerged without evidence of any brain volume differences between the patients and their controls as depicted by high-resolution MRI. This speaks for a dissociation between functional and structural alterations in TLE. BMJ Publishing Group 2020-09-21 /pmc/articles/PMC7903167/ /pubmed/33681800 http://dx.doi.org/10.1136/bmjno-2020-000077 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Original Research
Dordevic, Milos
Gruber, Julia
Schmitt, Friedhelm C
Mueller, Notger
Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
title Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
title_full Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
title_fullStr Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
title_full_unstemmed Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
title_short Impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
title_sort impairments in path integration, rotational memory and balancing in patients with temporal lobe epilepsy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903167/
https://www.ncbi.nlm.nih.gov/pubmed/33681800
http://dx.doi.org/10.1136/bmjno-2020-000077
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