Plegia to walking: AHSCBMT in severe NMOSD relapse

OBJECTIVES: Neuromyelitis optica is a devastating, relapsing, inflammatory, autoimmune disorder characterised in large part by attacks of optic neuritis and transverse myelitis causing blindness and plegia in many patients. Eighty-three per cent of patients with transverse myelitic attacks and 67% o...

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Detalles Bibliográficos
Autores principales: Carlisle, Nicola, Hari, Parameswaran, Brod, Staley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903183/
https://www.ncbi.nlm.nih.gov/pubmed/33681798
http://dx.doi.org/10.1136/bmjno-2020-000073
Descripción
Sumario:OBJECTIVES: Neuromyelitis optica is a devastating, relapsing, inflammatory, autoimmune disorder characterised in large part by attacks of optic neuritis and transverse myelitis causing blindness and plegia in many patients. Eighty-three per cent of patients with transverse myelitic attacks and 67% of patients with optic neuritis attacks have no or a partial recovery. METHODS: Results from The European Group for Blood and Marrow Transplantation Autoimmune Diseases Working Party imply failure of autologous haematopoietic stem cell bone marrow transplantation. RESULTS AND CONCLUSION: We present a case that despite eventual relapse, made a remarkable functional recovery after bone marrow transplantation which may justify bone marrow transplantation in severe cases.

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