Cargando…
Praktische Aspekte von COVID-19-Obduktionen
BACKGROUND: The COVID-19 pandemic represents a so far unknown challenge for the medical community. Autopsies are important for studying this disease, but their safety was challenged at the beginning of the pandemic. OBJECTIVES: To determine whether COVID-19 autopsies can be performed under existing...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Medizin
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903213/ https://www.ncbi.nlm.nih.gov/pubmed/33625535 http://dx.doi.org/10.1007/s00292-021-00925-w |
_version_ | 1783654692284268544 |
---|---|
author | Boor, Peter Eichhorn, Philip Hartmann, Arndt Lax, Sigurd F. Märkl, Bruno Menter, Thomas Skok, Kristijan Slotta-Huspenina, Julia von Stillfried, Saskia Tzankov, Alexandar Weirich, Gregor |
author_facet | Boor, Peter Eichhorn, Philip Hartmann, Arndt Lax, Sigurd F. Märkl, Bruno Menter, Thomas Skok, Kristijan Slotta-Huspenina, Julia von Stillfried, Saskia Tzankov, Alexandar Weirich, Gregor |
author_sort | Boor, Peter |
collection | PubMed |
description | BACKGROUND: The COVID-19 pandemic represents a so far unknown challenge for the medical community. Autopsies are important for studying this disease, but their safety was challenged at the beginning of the pandemic. OBJECTIVES: To determine whether COVID-19 autopsies can be performed under existing legal conditions and which safety standards are required. MATERIALS AND METHODS: The autopsy procedure undertaken in five institutions in Germany, Austria, and Switzerland is detailed with respect to legal and safety standards. RESULTS: In all institutions the autopsies were performed in technically feasible rooms. The personal equipment consisted of functional clothing including a disposable gown and apron, a surgical cap, eye protection, FFP‑3 masks, and two pairs of gloves. In four institutions, complete autopsies were performed; in one institution the ultrasound-guided biopsy within the postmortal imaging and biopsy program. The latter does not allow the appreciation of gross organ pathology; however, it is able to retrieve standardized biopsies for diagnostic and research purposes. Several scientific articles in highly ranked journals resulted from these autopsies and allowed deep insights into organ damage and conclusions to better understand the pathomechanisms. Viral RNA was frequently detectable in the COVID-19 deceased, but the issue of infectivity remains unresolved and it is questionable if Ct values are greater than 30. CONCLUSIONS: With appropriate safeguards, autopsies of people who have died from COVID-19 can be performed safely and are highly relevant to medical research. |
format | Online Article Text |
id | pubmed-7903213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Medizin |
record_format | MEDLINE/PubMed |
spelling | pubmed-79032132021-02-24 Praktische Aspekte von COVID-19-Obduktionen Boor, Peter Eichhorn, Philip Hartmann, Arndt Lax, Sigurd F. Märkl, Bruno Menter, Thomas Skok, Kristijan Slotta-Huspenina, Julia von Stillfried, Saskia Tzankov, Alexandar Weirich, Gregor Pathologe Schwerpunkt: COVID-19 BACKGROUND: The COVID-19 pandemic represents a so far unknown challenge for the medical community. Autopsies are important for studying this disease, but their safety was challenged at the beginning of the pandemic. OBJECTIVES: To determine whether COVID-19 autopsies can be performed under existing legal conditions and which safety standards are required. MATERIALS AND METHODS: The autopsy procedure undertaken in five institutions in Germany, Austria, and Switzerland is detailed with respect to legal and safety standards. RESULTS: In all institutions the autopsies were performed in technically feasible rooms. The personal equipment consisted of functional clothing including a disposable gown and apron, a surgical cap, eye protection, FFP‑3 masks, and two pairs of gloves. In four institutions, complete autopsies were performed; in one institution the ultrasound-guided biopsy within the postmortal imaging and biopsy program. The latter does not allow the appreciation of gross organ pathology; however, it is able to retrieve standardized biopsies for diagnostic and research purposes. Several scientific articles in highly ranked journals resulted from these autopsies and allowed deep insights into organ damage and conclusions to better understand the pathomechanisms. Viral RNA was frequently detectable in the COVID-19 deceased, but the issue of infectivity remains unresolved and it is questionable if Ct values are greater than 30. CONCLUSIONS: With appropriate safeguards, autopsies of people who have died from COVID-19 can be performed safely and are highly relevant to medical research. Springer Medizin 2021-02-24 2021 /pmc/articles/PMC7903213/ /pubmed/33625535 http://dx.doi.org/10.1007/s00292-021-00925-w Text en © Springer Medizin Verlag GmbH, ein Teil von Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Schwerpunkt: COVID-19 Boor, Peter Eichhorn, Philip Hartmann, Arndt Lax, Sigurd F. Märkl, Bruno Menter, Thomas Skok, Kristijan Slotta-Huspenina, Julia von Stillfried, Saskia Tzankov, Alexandar Weirich, Gregor Praktische Aspekte von COVID-19-Obduktionen |
title | Praktische Aspekte von COVID-19-Obduktionen |
title_full | Praktische Aspekte von COVID-19-Obduktionen |
title_fullStr | Praktische Aspekte von COVID-19-Obduktionen |
title_full_unstemmed | Praktische Aspekte von COVID-19-Obduktionen |
title_short | Praktische Aspekte von COVID-19-Obduktionen |
title_sort | praktische aspekte von covid-19-obduktionen |
topic | Schwerpunkt: COVID-19 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903213/ https://www.ncbi.nlm.nih.gov/pubmed/33625535 http://dx.doi.org/10.1007/s00292-021-00925-w |
work_keys_str_mv | AT boorpeter praktischeaspektevoncovid19obduktionen AT eichhornphilip praktischeaspektevoncovid19obduktionen AT hartmannarndt praktischeaspektevoncovid19obduktionen AT laxsigurdf praktischeaspektevoncovid19obduktionen AT marklbruno praktischeaspektevoncovid19obduktionen AT menterthomas praktischeaspektevoncovid19obduktionen AT skokkristijan praktischeaspektevoncovid19obduktionen AT slottahuspeninajulia praktischeaspektevoncovid19obduktionen AT vonstillfriedsaskia praktischeaspektevoncovid19obduktionen AT tzankovalexandar praktischeaspektevoncovid19obduktionen AT weirichgregor praktischeaspektevoncovid19obduktionen |