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Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient sho...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903271/ https://www.ncbi.nlm.nih.gov/pubmed/33450897 http://dx.doi.org/10.3390/curroncol28010046 |
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author | Javed, Sidra |
author_facet | Javed, Sidra |
author_sort | Javed, Sidra |
collection | PubMed |
description | Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient showed signs of tumor lysis syndrome (TLS), leading to urate nephropathy requiring urgent hemodialysis. Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer. It is challenging to recognize features of TLS in a case such as this with an unknown diagnosis. In the case of an established diagnosis of malignancy, however, checking baseline renal function, uric acid, lactate dehydrogenase (LDH), potassium, and phosphate to monitor for TLS as well as considering urate lowering therapy can help prevent adverse outcomes. |
format | Online Article Text |
id | pubmed-7903271 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-79032712021-02-25 Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer Javed, Sidra Curr Oncol Case Report Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient showed signs of tumor lysis syndrome (TLS), leading to urate nephropathy requiring urgent hemodialysis. Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer. It is challenging to recognize features of TLS in a case such as this with an unknown diagnosis. In the case of an established diagnosis of malignancy, however, checking baseline renal function, uric acid, lactate dehydrogenase (LDH), potassium, and phosphate to monitor for TLS as well as considering urate lowering therapy can help prevent adverse outcomes. MDPI 2021-01-13 /pmc/articles/PMC7903271/ /pubmed/33450897 http://dx.doi.org/10.3390/curroncol28010046 Text en © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Javed, Sidra Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer |
title | Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer |
title_full | Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer |
title_fullStr | Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer |
title_full_unstemmed | Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer |
title_short | Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer |
title_sort | urate nephropathy from tumor lysis syndrome in an undiagnosed case of prostate cancer |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903271/ https://www.ncbi.nlm.nih.gov/pubmed/33450897 http://dx.doi.org/10.3390/curroncol28010046 |
work_keys_str_mv | AT javedsidra uratenephropathyfromtumorlysissyndromeinanundiagnosedcaseofprostatecancer |