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Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer

Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient sho...

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Detalles Bibliográficos
Autor principal: Javed, Sidra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903271/
https://www.ncbi.nlm.nih.gov/pubmed/33450897
http://dx.doi.org/10.3390/curroncol28010046
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author Javed, Sidra
author_facet Javed, Sidra
author_sort Javed, Sidra
collection PubMed
description Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient showed signs of tumor lysis syndrome (TLS), leading to urate nephropathy requiring urgent hemodialysis. Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer. It is challenging to recognize features of TLS in a case such as this with an unknown diagnosis. In the case of an established diagnosis of malignancy, however, checking baseline renal function, uric acid, lactate dehydrogenase (LDH), potassium, and phosphate to monitor for TLS as well as considering urate lowering therapy can help prevent adverse outcomes.
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spelling pubmed-79032712021-02-25 Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer Javed, Sidra Curr Oncol Case Report Prostate cancer can masquerade as just normocytic anemia and thrombocytopenia, thrombotic thrombocytopenic purpura (TTP), hemolytic uremic syndrome (HUS), or tumor lysis syndrome (TLS). We are reporting an intriguing case of metastatic prostate cancer which remained undiagnosed until the patient showed signs of tumor lysis syndrome (TLS), leading to urate nephropathy requiring urgent hemodialysis. Tumor lysis syndrome is an oncological emergency but an exceedingly rare complication in non-hematological malignancies, including prostate cancer. It is challenging to recognize features of TLS in a case such as this with an unknown diagnosis. In the case of an established diagnosis of malignancy, however, checking baseline renal function, uric acid, lactate dehydrogenase (LDH), potassium, and phosphate to monitor for TLS as well as considering urate lowering therapy can help prevent adverse outcomes. MDPI 2021-01-13 /pmc/articles/PMC7903271/ /pubmed/33450897 http://dx.doi.org/10.3390/curroncol28010046 Text en © 2021 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Javed, Sidra
Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
title Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
title_full Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
title_fullStr Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
title_full_unstemmed Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
title_short Urate Nephropathy from Tumor Lysis Syndrome in an Undiagnosed Case of Prostate Cancer
title_sort urate nephropathy from tumor lysis syndrome in an undiagnosed case of prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903271/
https://www.ncbi.nlm.nih.gov/pubmed/33450897
http://dx.doi.org/10.3390/curroncol28010046
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