Gαo is a major determinant of cAMP signaling in the pathophysiology of movement disorders

The G protein alpha subunit o (Gαo) is one of the most abundant proteins in the nervous system, and pathogenic mutations in its gene (GNAO1) cause movement disorder. However, the function of Gαo is ill defined mechanistically. Here, we show that Gαo dictates neuromodulatory responsiveness of striata...

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Detalles Bibliográficos
Autores principales: Muntean, Brian S., Masuho, Ikuo, Dao, Maria, Sutton, Laurie P., Zucca, Stefano, Iwamoto, Hideki, Patil, Dipak N., Wang, Dandan, Birnbaumer, Lutz, Blakely, Randy D., Grill, Brock, Martemyanov, Kirill A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903328/
https://www.ncbi.nlm.nih.gov/pubmed/33535037
http://dx.doi.org/10.1016/j.celrep.2021.108718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903328/
https://www.ncbi.nlm.nih.gov/pubmed/33535037
http://dx.doi.org/10.1016/j.celrep.2021.108718

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