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Sox2 modulation increases naïve pluripotency plasticity

Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low). Sox2-low nPSCs do not show impaired neuroectoderm spe...

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Detalles Bibliográficos
Autores principales:	Tremble, Kathryn C., Stirparo, Giuliano G., Bates, Lawrence E., Maskalenka, Katsiaryna, Stuart, Hannah T., Jones, Kenneth, Andersson-Rolf, Amanda, Radzisheuskaya, Aliaksandra, Koo, Bon-Kyoung, Bertone, Paul, Silva, José C.R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903329/ https://www.ncbi.nlm.nih.gov/pubmed/33665571 http://dx.doi.org/10.1016/j.isci.2021.102153

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