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Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study

BACKGROUND: Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression....

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Autores principales: Tran, Diem Ngoc Hong, Hwang, I-Hsuan, Chen, Fun-Jou, Tseng, Yuan-Pu, Chang, Ching-Mao, Tsai, Shih-Jen, Yang, Jen-Lin, Wu, Ta-Peng, Hsu, Chung-Hua, Chen, Fang-Pey, Kung, Yen-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903348/
https://www.ncbi.nlm.nih.gov/pubmed/33665095
http://dx.doi.org/10.1016/j.imr.2020.100707
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author Tran, Diem Ngoc Hong
Hwang, I-Hsuan
Chen, Fun-Jou
Tseng, Yuan-Pu
Chang, Ching-Mao
Tsai, Shih-Jen
Yang, Jen-Lin
Wu, Ta-Peng
Hsu, Chung-Hua
Chen, Fang-Pey
Kung, Yen-Ying
author_facet Tran, Diem Ngoc Hong
Hwang, I-Hsuan
Chen, Fun-Jou
Tseng, Yuan-Pu
Chang, Ching-Mao
Tsai, Shih-Jen
Yang, Jen-Lin
Wu, Ta-Peng
Hsu, Chung-Hua
Chen, Fang-Pey
Kung, Yen-Ying
author_sort Tran, Diem Ngoc Hong
collection PubMed
description BACKGROUND: Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications. METHODS: All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products. RESULTS: There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was Gan-Mai-Da-Zao-Tang (12.19%), while Suan-Zao-Ren (3.99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of Gan-Mai-Da-Zao-Tang, Jia-Wei-Xiao-Yao-San, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, He-Huan-Pi, Yuan-Zhi and Shi-Chang-Pu. CONCLUSIONS: This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD.
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spelling pubmed-79033482021-03-03 Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study Tran, Diem Ngoc Hong Hwang, I-Hsuan Chen, Fun-Jou Tseng, Yuan-Pu Chang, Ching-Mao Tsai, Shih-Jen Yang, Jen-Lin Wu, Ta-Peng Hsu, Chung-Hua Chen, Fang-Pey Kung, Yen-Ying Integr Med Res Original Article BACKGROUND: Depressive disorders (DD) affect not only mood and behavior but also various physical functions. Traditional Chinese medicine (TCM) has been shown to have some benefits in treating DD. However, one formula or one single herb might be not show high efficacy when used to treat depression. Thus, this study aimed to examine the core prescription pattern of Chinese herbal medicine (CHM) among patients with DD in Taiwan as a reference for related research and clinical applications. METHODS: All patients, who had been diagnosed with major depressive disorder or minor depression or dysthymia without any other baseline diseases and had at least one CHM outpatient clinical visit from 2002 to 2011, were extracted from three randomly sampled cohorts, namely the 2000, 2005 and 2010 cohorts of the National Health Insurance Research Database (NHIRD) of Taiwan. The collected data was analyzed to explore the patterns of herbal products. RESULTS: There were 197,146 patients with a diagnosis of DD and of these 1806 subjects had only a diagnosis of DD and utilized CHM. The most common formula was Gan-Mai-Da-Zao-Tang (12.19%), while Suan-Zao-Ren (3.99%) was the most commonly prescribed single herb. The core pattern of prescriptions consisted of a combination of Gan-Mai-Da-Zao-Tang, Jia-Wei-Xiao-Yao-San, Chai-Hu-Jia-Long-Gu-Mu-Li-Tang, He-Huan-Pi, Yuan-Zhi and Shi-Chang-Pu. CONCLUSIONS: This study describes the CHM core prescription pattern used to treat patients in Taiwan with DD and it is a potential candidate for study in future pharmacological or clinical trials targeting DD. Elsevier 2021-09 2020-12-04 /pmc/articles/PMC7903348/ /pubmed/33665095 http://dx.doi.org/10.1016/j.imr.2020.100707 Text en © 2021 Published by Elsevier B.V. on behalf of Korea Institute of Oriental Medicine. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Tran, Diem Ngoc Hong
Hwang, I-Hsuan
Chen, Fun-Jou
Tseng, Yuan-Pu
Chang, Ching-Mao
Tsai, Shih-Jen
Yang, Jen-Lin
Wu, Ta-Peng
Hsu, Chung-Hua
Chen, Fang-Pey
Kung, Yen-Ying
Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study
title Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study
title_full Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study
title_fullStr Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study
title_full_unstemmed Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study
title_short Core prescription pattern of Chinese herbal medicine for depressive disorders in Taiwan: a nationwide population-based study
title_sort core prescription pattern of chinese herbal medicine for depressive disorders in taiwan: a nationwide population-based study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903348/
https://www.ncbi.nlm.nih.gov/pubmed/33665095
http://dx.doi.org/10.1016/j.imr.2020.100707
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