Stress-induced NEDDylation promotes cytosolic protein aggregation through HDAC6 in a p62-dependent manner

Stress-coupled NEDDylation potentially regulates the aggregation of nuclear proteins, which could protect the nuclear ubiquitin-proteasome system from proteotoxic stress. However, it remains unclear how NEDDylation controls protein-aggregation responses to diverse stress conditions. Here, we identif...

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Detalles Bibliográficos
Autores principales: Kim, Soyeon, Kwon, Mira, Hwang, Yiseul, Yoon, Junghyun, Park, Sangwook, Kang, Ho Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903351/
https://www.ncbi.nlm.nih.gov/pubmed/33665565
http://dx.doi.org/10.1016/j.isci.2021.102146

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