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Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials

OBJECTIVE: To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins. DESIGN: Series of randomised, placebo controlled n-of-1 trials. SETTING: Primary care across 50 sites in the United Kingdom, December 2016 to April 2018. PARTIC...

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Autores principales: Herrett, Emily, Williamson, Elizabeth, Brack, Kieran, Beaumont, Danielle, Perkins, Alexander, Thayne, Andrew, Shakur-Still, Haleema, Roberts, Ian, Prowse, Danielle, Goldacre, Ben, van Staa, Tjeerd, MacDonald, Thomas M, Armitage, Jane, Wimborne, Jon, Melrose, Paula, Singh, Jayshireen, Brooks, Lucy, Moore, Michael, Hoffman, Maurice, Smeeth, Liam, Harmston, Rebecca, MacKenna, Brian, Symes, David, Norrie, John, Mills, Nicholas, Castro, Hannah, Youssouf, Nabila, Barrow, Collette, Kostrov, Sergey, Miah, Hakim, Thacker, Eve, Baldey, Melissa, Sowerby, Eleanor, Harding, Nicola, Timcke, Gail, Macleod, Alison, Lomax, Karen, Wells, Nigel, Pierre, Emma, Baker, Tom, Bratten, Carla, Forshaw, Karen, Clark, Daniel, Fox, Selina, Hubbard, Rachel, Crichton, David, Alsindi, Nabeel, Hayes, Mandy, Elliot, Keith (Peter), Fox, Robin, Stanford, Jane, Ackland, Emily, Strong, George, Kelly, Debbie, Malhotra, Dev, Gandhi, Dipti, Foster, Gillian, Exley, Diane, Brayford, Dawn, Nuttall, Theresa, Corbett, Clare, Anderton, Nicola, Hughes, Gwyn, Turner, Sian, Roberts, Sarah, Brown, David, Fairhead, Susan, Sutcliffe, Karen, Boon, Mark, Dirienzo, Paula, Ellor, Kay, Chowhan, Hasan, Townrow, Amy, Rowles, Tracey, Hipps, Debbie, Perry, Geoffrey, Ayers, Amanda, Cooper, Rebecca, Harley, Sara, Parsons, Lesley, Selby, Ann, Hood, Regan, Zoon, Elizabeth, Wraith, Lucy, Peterson, Vicky, Pretty, Jackie, Dhillon, Narinder, Wearne, John, Moss, Sandra, Maitland, Kate, Edge, Catherine, Brown, Susan, Mackay-Thomas, Stuart, Pearson, Heather, Deas, Ewan, Yelland, Lesley, Jones, Helen, Rogers, Stephen, Huckle, Ian, Dernedde, Carsten, Mansfield, Caroline, Leishman, Heather, Howard, Jordan, Wright, Chris, Ashworth, Mark, Kumar, Satinder, Guerreiro, Catarina, Hartley, David, Gordon, Sally, Forrest, Carolyn, Gibson, Andy, Howe, Laura, Whitwell, John, Nazareth, Irwin, Coco-Bassey, Letitia, Walters, Kate, Mburu, Jaqueline, Chetwood, Crystal, Dowding, Lynne, Williams, Alison, Richards, Nikki, Nelson, Mini, Chadwick, Emma, Mingaye, Helen, Mathukia, Mehul, Mburu, Jacqueline, Swinburn, Anna, Tomakin, Janeth, Valasevich, Valentina, Jones, Hywel, Bannister, Joanne, Edwards, Emma, McDowall, Morag, Hall, Beverley, Permain, Helen, Peacock, Nigel, Harrison, Carol, Parsons, Lorraine, Kee, Chuin, McLaren, Paula, Le Maitre, Sherard, Nash, Helen, Evans, Stephanie, Evans, Rachel, Miller, Stephen, Agarwal, Pooja, Booth, Oliver, Mayhew, Victoria, Peat, Alison, Manzur, Maqsood, Chauhan, Umesh, Miller, Lesley, O’Connell-Binns, Katie, Wetherell, Simon, Moon, Sam, Bland, Sarah, Leach, Julia, Sloan, Mark, Shepherd, Christine, Dyer-Smith, Ross, Derks, Maarten, Read, Karen, Button, Jodie, Hadley-Brown, Martin, Smith, Sandra, Hutson, Caroline, Stewart, Barbara, Norcott, Karen, Slattery, Andrew, Singh, Davinder, Fells, Rose, Foster, Susie, Tomlinson, Liz, Coutts, Michaela, Morgan, Kathryn, Cowling, David, Beldon, Joanna, Guest, Caite, Helme, Bruce, Tacagni, Daniel, Davies, Nikki, Sanders, Angela, Harris, Paul, Juhasz, Angela, Jenkins, Anne, Rakin, Kirsteen, Hayward-Allingham, Tracey, Kirby, Samantha, Jeyarajah, Kumani, Guss, Beata, Daukszewicz, Dorota, Ozcan, Yesim, Vivekanandaraja, Jaisun, Pandya, Preeti, Oldham, Stella, Roberts, Lindsey, Fuller, Julie, Khanbhai, Murtaza, Barnett, Jonathan, Toledo, Veridiana, Collier, David, Zak, Anne, James, Rebecca, Choudhury, Yasmin, Feely, Mary, Saxena, Manish, Shiel, Julian, Colclough, Julia, Butterworth, Elizabeth, Crumbie, Alison, Barlow, Jill, Pascall, Nicola Jayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903384/
https://www.ncbi.nlm.nih.gov/pubmed/33627334
http://dx.doi.org/10.1136/bmj.n135

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