Role of Phosphorylation and Hyperphosphorylation of Tau in Its Interaction with βα Dimeric Tubulin Studied from a Bioinformatics Perspective

BACKGROUND: Tau is a disordered Microtubule Associated Protein (MAP) which prefers to bind and stabilize microtubules. Phosphorylation of tau in particular enhances tautubulin interaction which otherwise detaches from tubulin during hyperphosphorylation. The reason behind their destabilization, deta...

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Detalles Bibliográficos
Autores principales: Dixit, Hrushikesh, Kumar C, Selvaa, Chaudhary, Ruchi, Thaker, Divya, Gadewal, Nikhil, Dasgupta, Debjani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Avicenna Research Institute 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7903436/
https://www.ncbi.nlm.nih.gov/pubmed/33680370
http://dx.doi.org/10.18502/ajmb.v13i1.4579

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